2-Methoxyfuranodiene B is a myrrh-associated furanosesquiterpenoid found in Commiphora myrrha resin and in some myrrh essential-oil GC-MS profiles. Archive evidence supports its identity and repeated occurrence in myrrh chemistry, while biological evidence is still preclinical and mostly limited to cell, zebrafish, and extract-level studies. It is better documented as a marker of myrrh's resin chemistry than as a stand-alone wellness ingredient.
Aroma and practical use
- Use the recorded myrrh-like, resinous, warm, balsamic, resin descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2020 Molecules abstract reported that 2-methoxyfuranodiene and 2-acetoxyfuranodiene isolated from Commiphora myrrh were highly cytotoxic in HepG2 and MCF-7 cells, and that both compounds induced apoptosis and cell-cycle arrest in treated HepG2 cells.
A 2020 Molecules abstract reported that 2-methoxyfuranodiene and 2-acetoxyfuranodiene isolated from Commiphora myrrh were highly cytotoxic in HepG2 and MCF-7 cells, and that both compounds induced apoptosis and cell-cycle arrest in treated HepG2 cells.
This experimental finding does not establish benefit, dose or safety in people using this blend.
The same abstract reported chronic zebrafish embryo toxicity after exposure longer than three days, supporting cautious safety framing around concentrated isolated compounds.
The same abstract reported chronic zebrafish embryo toxicity after exposure longer than three days, supporting cautious safety framing around concentrated isolated compounds.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 2024 PubMed abstract on Commiphora myrrha resin extracts identified 2-methoxyfuranodiene at 5.42% in the GC-MS profile of the tested extract alongside curzerene and beta-elemene.
A 2024 PubMed abstract on Commiphora myrrha resin extracts identified 2-methoxyfuranodiene at 5.42% in the GC-MS profile of the tested extract alongside curzerene and beta-elemene.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
unverified reference · No source provenance attachedNo CAS number or constituent-specific dermal limit was verified for the B isomer in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
The clearest accessible safety signal is indirect: isolated 2-methoxyfuranodiene showed chronic zebrafish embryo toxicity after multi-day exposure in a preclinical model.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Archive language should avoid implying consumer topical safety or therapeutic suitability because the current evidence base is mainly laboratory toxicology and extract chemistry.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
Apoptosis and cell-cycle arrest in cultured cells
A PubMed abstract for isolated myrrh furano-sesquiterpenoids reports that 2-methoxyfuranodiene induced apoptosis and cell-cycle arrest in treated HepG2 cells.
This experimental finding does not establish benefit, dose or safety in people using this blend.
No direct public citation is attached to this entry.
Anti-angiogenic signaling in zebrafish model
The same research line tested angiogenesis in transgenic zebrafish embryos, indicating a developmental-biology screening context rather than a validated human mechanism.
This experimental finding does not establish benefit, dose or safety in people using this blend.
No direct public citation is attached to this entry.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- A verified CAS number specific to 2-Methoxyfuranodiene B was not located in this pass.
- Most accessible bioactivity evidence uses isolated-compound cell assays or whole-resin extracts, not human clinical research.
- Direct odor-descriptor literature for the isolated B isomer is sparse; current aroma language is inferred from its repeated occurrence in myrrh resin chemistry.
- The numeric dermal reference lacks source provenance; a verified flag alone is insufficient.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.