2-Methylbutyl angelate is an angelic-acid ester best known in the archive as a recurrent constituent of Roman chamomile essential oil. Public data strongly support its identity and repeated occurrence in chamomile chemotypes, while direct constituent-level pharmacology and safety testing remain limited. It is best treated as an aroma-relevant ester with evidence grounded in GC-MS composition studies and reference databases.
Aroma and practical use
- Use the recorded fruity, green, apple-like, sweet-herbaceous descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
The EMA Roman chamomile assessment summarized 2-methylbutyl angelate at 13.0-20.3% in flower oil, placing it among the major esters of the oil.
The EMA Roman chamomile assessment summarized 2-methylbutyl angelate at 13.0-20.3% in flower oil, placing it among the major esters of the oil.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2022 Roman chamomile valorization study reported 2-methylbutyl angelate at 3.11-6.32% across six vegetation phases, confirming that its abundance shifts with harvest stage and processing context.
A 2022 Roman chamomile valorization study reported 2-methylbutyl angelate at 3.11-6.32% across six vegetation phases, confirming that its abundance shifts with harvest stage and processing context.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 1998 study comparing Roman chamomile oils reported 2-methylbutyl angelate around 18.2-20.3% with no major composition differences between the two oils studied.
A 1998 study comparing Roman chamomile oils reported 2-methylbutyl angelate around 18.2-20.3% with no major composition differences between the two oils studied.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
unverified reference · No source provenance attachedNo constituent-specific public dermal maximum or dedicated topical sensitization dataset was verified in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Available public evidence is stronger for occurrence and identity than for standalone toxicology.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
Likely hydrolyzed by carboxylesterases to 2-methylbutanol and angelic acid.
This is a chemistry-based inference from general ester metabolism literature, not a direct mechanistic study on 2-methylbutyl angelate.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- No direct human or animal pharmacology study focused on isolated 2-methylbutyl angelate was verified in this pass.
- No public constituent-specific dermal restriction was located.
- Mechanistic handling is inferred from general ester metabolism rather than direct testing on this molecule.
- The numeric dermal reference lacks source provenance; a verified flag alone is insufficient.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.