2-Tridecanone is a straight-chain methyl ketone found in wild tomato defense chemistry, some floral materials, and a small number of essential-oil profiles in the AromaForge archive. Compared with many trace aroma constituents, it has a useful evidence base for identity, plant-defense relevance, tick-repellency testing, and fragrance-safety review. The literature is still mostly ecological, entomological, or regulatory rather than human clinical, so the archive should frame 2-tridecanone as an aroma-and-defense constituent with preclinical repellent evidence, not as a medical active.
Aroma and practical use
- Use the recorded waxy, fatty, earthy, coconut-like descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2011 tick study reported that 2-tridecanone was 87% repellent to Amblyomma americanum at 12 hours in filter-paper assays and 85% repellent on cheesecloth at 6 hours under the tested conditions.
A 2011 tick study reported that 2-tridecanone was 87% repellent to Amblyomma americanum at 12 hours in filter-paper assays and 85% repellent on cheesecloth at 6 hours under the tested conditions.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 2001 wild-tomato study quantified 2-tridecanone among the methyl ketones produced in glandular trichomes, reinforcing its established role in tomato defense chemistry.
A 2001 wild-tomato study quantified 2-tridecanone among the methyl ketones produced in glandular trichomes, reinforcing its established role in tomato defense chemistry.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2019 Helicoverpa armigera paper reported that alcohol dehydrogenase 5 interacted with the plant toxin 2-tridecanone and contributed to protective responses in the insect model.
A 2019 Helicoverpa armigera paper reported that alcohol dehydrogenase 5 interacted with the plant toxin 2-tridecanone and contributed to protective responses in the insect model.
This experimental finding does not establish benefit, dose or safety in people using this blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
A 2022 RIFM fragrance ingredient safety assessment reported that the existing information supports use of 2-tridecanone as described in that assessment and noted no skin-sensitization concern under current declared levels of use based on read-across data.
The source assessment applies to its specified exposure and preparation; this entry is not an unrestricted-use clearance.
This pass did not verify human clinical safety or efficacy studies for isolated 2-tridecanone outside repellent-style entomology testing.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
arthropod_repellency_and_contact_defense
The best-supported functional role for 2-tridecanone is arthropod deterrence or repellency in plant-defense and tick-assay settings.
This experimental finding does not establish benefit, dose or safety in people using this blend.
insect_detox_gene_response
In cotton bollworm systems, 2-tridecanone exposure induces or interacts with detoxification machinery such as CYP6B6-responsive promoter regions and ADH5-linked protection pathways.
This experimental finding does not establish benefit, dose or safety in people using this blend.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (4)
- No human clinical trials focused on isolated 2-tridecanone were verified in this pass.
- Most direct literature is plant-defense, insect, or tick-repellency work rather than fragrance-consumer outcome data.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.