5-Hydroxy-cis-calamenene is an oxygenated sesquiterpene reported in several essential-oil composition studies and in the AromaForge amber distillate record. Public chemistry databases support its molecular formula and stereochemical identifiers, but this research pass did not verify a confident CAS number from a primary public source. Evidence is much thinner than for common fragrance ketones: accessible literature mainly documents occurrence in plant oils and mixed-oil bioactivity papers rather than isolated pharmacology or formal safety review. For archive use, it is best treated as a structurally identified but sparsely characterized constituent with clear sourcing gaps.
Aroma and practical use
- Use the recorded woody, resinous, smoky, amber-like, resin descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2017 Eugenia oil composition study reported the first detection of 5-hydroxy-cis-calamenene in Eugenia oils; the paper also measured antioxidant and cytotoxic activity for whole oils, not for isolated 5-hydroxy-cis-calamenene.
A 2017 Eugenia oil composition study reported the first detection of 5-hydroxy-cis-calamenene in Eugenia oils; the paper also measured antioxidant and cytotoxic activity for whole oils, not for isolated 5-hydroxy-cis-calamenene.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 2024 composition paper listed 5-hydroxy-cis-calamenene among identified components in essential oils from Myrcianthes storkii, adding occurrence support but not constituent-isolated bioactivity data.
A 2024 composition paper listed 5-hydroxy-cis-calamenene among identified components in essential oils from Myrcianthes storkii, adding occurrence support but not constituent-isolated bioactivity data.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
unverified reference · No source provenance attachedNo dedicated public safety assessment, dermal limit, or phototoxic review specific to 5-hydroxy-cis-calamenene was verified in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Because the evidence is mostly occurrence-level and mixed-oil literature, safety conclusions should not be inferred from broader calamenene-family reports without compound-specific verification.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (6)
- No confident public CAS number was verified from a primary source in this pass, so the CAS field remains null.
- No isolated constituent study was verified for mechanism, dermal sensitization, or phototoxicity.
- Most bioactivity mentions are attached to whole essential oils containing this constituent, which is not enough to attribute the effect to 5-hydroxy-cis-calamenene alone.
- Safety-verification pass (2026-07-13): web search found no IFRA, Tisserand & Young, EU Annex III, or peer-reviewed dermal-limit/phototoxicity/sensitization data specific to 5-hydroxy-cis-calamenene; the existing dermal_limit_pct value of 20 has no locatable source and should be treated as an unverified placeholder pending a dedicated citation.
- The numeric dermal reference lacks source provenance; a verified flag alone is insufficient.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.