Agarospirol is a sesquiterpene alcohol and characteristic agarwood marker compound documented in the AromaForge archive. The reviewed literature ties agarospirol mainly to agarwood identity studies and a small number of preclinical pharmacology papers, including mouse central nervous system and writhing models plus a broader agarwood-oil anti-inflammatory study. Evidence remains preclinical and should be read as reported constituent research rather than a medical claim.
Chemical identity and composition
PubChem classifies agarospirol as a sesquiterpenoid and lists the molecular formula C15H26O. In the archive's linked agarwood oil record, agarospirol was reported at 0.80-4.03% in Aquilaria sinensis hydrodistilled oils, while another reviewed agarwood-oil paper described agarospirol as a major constituent at 12.5% in its tested oil.
Aroma and practical use
- Use the recorded spicy, peppery, woody descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Compare the recorded goal signals with the intended purpose, while keeping model assumptions separate from observed study outcomes.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
central nervous system activity
An abstracted mouse study reported that isolated agarospirol prolonged hexobarbital-induced sleeping time, reduced spontaneous motility, lowered rectal temperature, decreased stimulant-induced motility, and increased brain homovanillic acid, with the authors concluding that agarospirol could be considered neuroleptic-like.
Measured: sleep time, hypothermia, motility, brain metabolite changes
This experimental finding does not establish benefit, dose or safety in people using this blend.
antinociceptive related research
A follow-up abstract reported that agarospirol was among six sesquiterpenoids isolated from oriental incenses that inhibited acetic acid-induced writhing in mice, although the mechanistic opioid-receptor work in that paper focused more specifically on alpha-santalol.
Measured: acetic acid-induced writhing
This experimental finding does not establish benefit, dose or safety in people using this blend.
anti inflammatory related research
Agarwood oil containing agarospirol at 12.5% significantly reduced ear thickness, ear weight, oxidative stress, and pro-inflammatory cytokines in a dose-dependent mouse ear-edema model, while the same paper's docking analysis suggested agarospirol among the more active anti-inflammatory constituents.
Measured: ear edema, MDA activity, IL-1beta, IL-6, TNF-alpha
This experimental finding does not establish benefit, dose or safety in people using this blend.
How it contributes to goal calculations
Model markers guide the formulation score. They are separate from the source findings above.
Use concerns and concentration limits
Sensitization concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
No constituent-specific dermal limit or IFRA restriction was located in the reviewed public sources.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
The reviewed activity literature for agarospirol is preclinical and includes central nervous system effects in mice, so consumer-facing summaries should avoid implied sedative or therapeutic claims.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
dopaminergic turnover signal
In mice, agarospirol increased brain homovanillic acid without materially changing monoamine levels, which the authors interpreted as consistent with neuroleptic-like central nervous system activity.
This experimental finding does not establish benefit, dose or safety in people using this blend.
predicted anti inflammatory target binding
A docking and QSAR paper on agarwood oil constituents reported that agarospirol showed relatively strong predicted binding to major anti-inflammatory and immunomodulatory receptors within that in silico model.
This experimental finding does not establish benefit, dose or safety in people using this blend.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- No human clinical studies specific to isolated agarospirol were located in the reviewed public sources.
- Constituent-specific sensitization, dermal-limit, and phototoxicity data were not located in the reviewed public sources.
- Part of the anti-inflammatory mechanism evidence is indirect because the cited topical inflammation paper tested whole agarwood oil plus in-silico constituent modeling rather than isolated agarospirol alone.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.