Cadalene is an aromatic sesquiterpene hydrocarbon found in a smaller set of woody, fossil-resin, and unusual cypress-like oils in the AromaForge archive. The strongest public evidence supports identity, occurrence, and its role as a higher-plant or paleobotanical biomarker. Direct health-related evidence is weak and somewhat messy because the literature often focuses on hydroxy- or methoxy-cadalene derivatives rather than cadalene itself, so this record should stay conservative and chemistry-led.
Chemical identity and composition
PubChem and NIST both resolve cadalene as C15H18 with an alkylated naphthalene structure and CAS 483-78-3. That live identity conflicts with two local oil records that currently carry 483-76-1, so this constituent file keeps the external identity value while leaving oil files untouched. In local occurrence data, cadalene is a named principal constituent of amber fossilised oil and a quantified 3.30% constituent of jade wood essential oil.
Aroma and practical use
- Use the recorded dry, woody, ambery, resinous, resin descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2013 phytochemical paper isolated cadalene from Chromolaena odorata leaves and confirmed it as 1,6-dimethyl-4-(1-methylethyl)naphthalene, expanding occurrence evidence but not establishing strong stand-alone activity for the parent compound.
A 2013 phytochemical paper isolated cadalene from Chromolaena odorata leaves and confirmed it as 1,6-dimethyl-4-(1-methylethyl)naphthalene, expanding occurrence evidence but not establishing strong stand-alone activity for the parent compound.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2004 mouse study reported antioxidative effects and higher glutathione levels for 7-hydroxy-3-methoxy-cadalene in an NNK-induced lung tumorigenesis model, but that evidence applies to a substituted cadalene derivative rather than cadalene itself.
A 2004 mouse study reported antioxidative effects and higher glutathione levels for 7-hydroxy-3-methoxy-cadalene in an NNK-induced lung tumorigenesis model, but that evidence applies to a substituted cadalene derivative rather than cadalene itself.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 2007 xenograft paper tested cadalene as an anticancer scaffold and reported that glycosylated cadalene derivatives were less toxic, more soluble, and reduced tumor size in mice, again pointing to derivative optimization rather than validated efficacy of the parent constituent.
A 2007 xenograft paper tested cadalene as an anticancer scaffold and reported that glycosylated cadalene derivatives were less toxic, more soluble, and reduced tumor size in mice, again pointing to derivative optimization rather than validated efficacy of the parent constituent.
This experimental finding does not establish benefit, dose or safety in people using this blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
No constituent-specific IFRA restriction, dermal limit, or human tolerability study for isolated cadalene was verified in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Because cadalene is an aromatic hydrocarbon and the direct safety literature located was sparse, archive copy should avoid overconfident topical or inhalation safety language for the isolated constituent.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Derivative studies should not be conflated with safety or efficacy evidence for unsubstituted cadalene.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
no validated human mechanism for parent compound
No constituent-specific human mechanism was verified for cadalene itself in the reviewed public sources.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
oxidative stress related signal from derivative literature
Derivative-focused studies suggest oxidative-stress and apoptosis-linked activity for hydroxy- or carbamate-substituted cadalene analogues, but that should be treated as scaffold-adjacent evidence rather than proof for the parent hydrocarbon.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- Most accessible bioactivity data concerns hydroxy-, methoxy-, or carbamate-substituted cadalenes rather than the parent constituent.
- No human clinical studies specific to cadalene were located in the reviewed public sources.
- Constituent-specific dermal, inhalation, reproductive-safety, and phototoxicity data were not verified in this pass.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.