Calacorene is a sesquiterpene hydrocarbon name used somewhat loosely in public volatile-oil literature and trade materials, often pointing to the alpha-calacorene stereochemical record rather than a completely separate constituent identity. In the AromaForge archive, the current `calacorene` usage appears in amber fossilized oil while a separate `alpha_calacorene` record already exists for the more explicit stereochemical form. The best-supported position is therefore identity-first: public databases tie the simple name Calacorene to the alpha-calacorene synonym cluster with CAS 21391-99-1, while standalone pharmacology and safety literature remain sparse.
Chemical identity and composition
PubChem name resolution for calacorene returns two closely related records: a non-stereospecific 3,4-dihydrocadalene entry and a stereospecific alpha-Calacorene entry. The archive's amber oil record assigns CAS 21391-99-1 to calacorene, matching the alpha-Calacorene / Calacorene synonym cluster in PubChem and NIST. Because trade and analytical sources do not always specify the stereoisomer, this profile treats calacorene as an alias-level bridge record rather than claiming a richer standalone evidence base.
Aroma and practical use
- Use the recorded woody, dry, resinous, sesquiterpenic, resin descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
amber oil occurrence
A public amber-oil certificate used in the archive lists calacorene among the primary constituents of fossilized amber distillate, but does not disclose its percentage.
Measured: named primary constituent list
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
alpha calacorene in mixed oil antimicrobial study
A PubMed-indexed abstract reported alpha-calacorene at 4.97% in Teucrium montanum essential oil and found antibacterial and antifungal activity for the whole oil, but did not isolate calacorene as the confirmed active principle.
Measured: oil composition plus whole-oil antimicrobial activity
This experimental finding does not establish benefit, dose or safety in people using this blend.
volatile marker occurrence
An open-access profiling study selected calacorene among marker volatiles distinguishing Selaginella doederleinii samples from different habitats, supporting occurrence but not constituent-specific bioactivity claims.
Measured: volatile marker selection
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
No constituent-specific dermal limit, IFRA restriction, sensitization threshold, or phototoxicity study for calacorene was located in the reviewed public sources for this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Because the public evidence base is dominated by identity and occurrence data, safety language for isolated calacorene should stay conservative.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (6)
- Public sources often blur calacorene and alpha-calacorene naming, so stereochemical precision is limited unless the source explicitly specifies the isomer.
- No human studies specific to isolated calacorene were located in the reviewed public sources.
- No direct constituent-specific mechanism paper was located; accessible bioactivity discussion is indirect through mixed-oil or composition papers.
- A c6 verification search (2026-07-13) found no RIFM/IFRA safety assessment or dermal-limit citation for calacorene/alpha-calacorene (CAS 21391-99-1); the prior unsourced 25% dermal_limit_pct and sensitizing:true were corrected to null.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.