Cedrene is a cedarwood-linked sesquiterpene hydrocarbon name that is often used broadly for cedar oil cedrene fractions and, in stricter chemistry contexts, for specific alpha- or beta-cedrene isomers. In the AromaForge archive, the direct evidence base is strongest for identity, occurrence, and a small amount of preclinical research tied to cedrene isomers rather than to an undifferentiated generic cedrene standard. That makes cedrene useful as a cedarwood composition marker with limited laboratory activity data and clear limits on human-effect interpretation.
Chemical identity and composition
PubChem resolves generic cedrene to CID 521207 with formula C15H24 and the tricyclic cedrane hydrocarbon skeleton name 2,6,6,8-tetramethyltricyclo[5.3.1.01,5]undec-8-ene. NIST indexes generic cedrene under CAS 11028-42-5, while local oil records show that archive usage can refer either to a generic cedrene peak or to the better-defined alpha- and beta-cedrene isomers in cedarwood profiles.
Aroma and practical use
- Use the recorded woody, dry, cedarwood, smoky, cedar-like descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
western juniper antimicrobial testing
A 2001 wood-oil study reported that alpha- and beta-cedrene from western juniper were active components in antimicrobial testing against the anaerobic bacteria and yeast panel used in that paper.
Measured: broth-assay antimicrobial activity
This experimental finding does not establish benefit, dose or safety in people using this blend.
alpha cedrene or10j5 signaling
A 2017 Scientific Reports paper identified alpha-cedrene as an OR10J5 agonist and reported reduced lipid accumulation in human hepatocytes together with receptor-linked metabolic signaling in a mouse hepatic-steatosis program.
Measured: lipid accumulation and receptor-linked signaling
This experimental finding does not establish benefit, dose or safety in people using this blend.
beta cedrene cyp2b6 inhibition
A 2014 microsome study reported that beta-cedrene competitively inhibited CYP2B6-mediated bupropion hydroxylation with a low-micromolar inhibition constant, suggesting a constituent-level drug-metabolism interaction signal in vitro.
Measured: CYP2B6-mediated bupropion hydroxylase inhibition
This experimental finding does not establish benefit, dose or safety in people using this blend.
Use concerns and concentration limits
Sensitization concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
recorded reference · RIFM fragrance ingredient safety assessment, cedrene, CAS 11028-42-5 (NESIL 3500 micrograms/cm2; reported IFRA leave-on maximum 0.38%, moderate-confidence indexed source)No constituent-specific dermal limit, phototoxic restriction, or human tolerability study was verified for generic cedrene in the reviewed public sources.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Because the published activity data are tied mainly to alpha- and beta-cedrene isomers, generic cedrene records should avoid implying that every cedrene-labeled material has the same biological profile.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
or10j5 camp pka signaling from alpha cedrene literature
The clearest mechanistic signal connected to the cedrene name comes from alpha-cedrene papers reporting OR10J5 or MOR23-linked cAMP-PKA signaling in hepatocyte and skeletal-muscle models.
This experimental finding does not establish benefit, dose or safety in people using this blend.
No direct public citation is attached to this entry.
cyp2b6 interaction signal from beta cedrene literature
A human liver microsome study reported potent competitive inhibition of CYP2B6-mediated bupropion hydroxylation by beta-cedrene, which is relevant as an early interaction flag for the cedrene isomer family.
This experimental finding does not establish benefit, dose or safety in people using this blend.
No direct public citation is attached to this entry.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (4)
- The generic cedrene label is chemically less specific than alpha-cedrene or beta-cedrene, and some sources use it loosely for cedarwood sesquiterpene fractions.
- No human clinical studies specific to generic cedrene were verified in this pass.
- The RIFM assessment PDF returned a server error on direct fetch during this pass; the NESIL and leave-on limit figures are corroborated via indexed search-result text and a secondary industry summary rather than a directly re-read full document, so confidence in the exact 0.38% figure is moderate rather than high.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.