cis-Caryophyllene is a sesquiterpene hydrocarbon reported as a minor constituent in essential-oil GC-MS profiles.
Chemical identity and composition
cis-Caryophyllene corresponds to isocaryophyllene (PubChem CID 5281522, CAS 118-65-0), the Z-isomer of the much more common (E)-beta-caryophyllene (CAS 87-44-5). Because it is a distinct stereoisomer from beta-caryophyllene, safety data published for beta-caryophyllene (e.g., RIFM/EU allergen-labeling determinations) should not be assumed to transfer directly to isolated isocaryophyllene.
Aroma and practical use
No aroma description is attached to this identity yet.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
There are no constituent-specific outcome findings in this report. No therapeutic benefit is inferred from its presence.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
No constituent-specific dermal limit, sensitization, or phototoxicity study for isolated isocaryophyllene (cis-caryophyllene) was located in the reviewed public sources for this pass; safety literature on the related trans-isomer beta-caryophyllene (CAS 87-44-5, RIFM assessment: no sensitization concern under current use levels, not phototoxic) exists but is not assumed to apply to this distinct stereoisomer.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- Minor GC-MS constituent added during composition completion; profile/SEO detail pending. Dermal limit, sensitization, and phototoxicity remain unverified for this specific stereoisomer. Follow-up web search (2026-07-13) again found only beta-caryophyllene (trans, CAS 87-44-5) safety data; no isocaryophyllene-specific dermal/sensitization/phototoxicity source located, so all safety fields remain unverified rather than read across from the trans isomer.
- No constituent-specific outcome findings are available in this report.
- No cited aroma description is available for this identity.
- No public source links are attached to this constituent report.
- No constituent-specific numeric dermal reference is available here.