cis-Shisool is a minor-to-secondary oxygenated monoterpene alcohol associated with shiso and perilla aroma profiles, especially green perilla leaf oil. In the public literature reviewed here, the evidence base is much stronger for identity and occurrence than for isolated pharmacology or safety testing. For AromaForge, the most defensible framing is that cis-shisool is a shiso-character marker constituent with limited standalone bioactivity evidence and an unresolved public CAS/identity trail for the isolated cis isomer.
Chemical identity and composition
Public sources consistently describe cis-shisool as the cis isomer of p-menth-8-en-7-ol / dihydroperilla alcohol. PubChem currently exposes a non-stereospecific shisool record for the core skeleton, while The Good Scents Company lists a cis-shisool entry with the synonym cyclohexanemethanol, 4-(1-methylethenyl)-, cis-. In the local archive, Takasago's Hokkaido green perilla table reports cis-shisool at 4.513 area% GC-FID in perilla shiso leaf oil.
Aroma and practical use
- Use the recorded green, mint-like, fresh, cooling descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A Food Chemistry survey of ten perilla accessions identified trans-shisool among the predominant volatile constituents across the tested leaf oils, supporting shisool-type alcohols as recurring markers in perilla chemoprofiles even though the paper did not isolate the cis isomer separately.
A Food Chemistry survey of ten perilla accessions identified trans-shisool among the predominant volatile constituents across the tested leaf oils, supporting shisool-type alcohols as recurring markers in perilla chemoprofiles even though the paper did not isolate the cis isomer separately.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Takasago's public Hokkaido green perilla GC-FID table listed cis-shisool at 4.513 area% and described it alongside perillaldehyde and limonene as part of the refreshing shiso aroma profile.
Takasago's public Hokkaido green perilla GC-FID table listed cis-shisool at 4.513 area% and described it alongside perillaldehyde and limonene as part of the refreshing shiso aroma profile.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
unverified reference · No source provenance attachedNo directly readable public IFRA standard, dermal limit, phototoxicity study, or dedicated toxicology paper was located for isolated cis-shisool in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
The Good Scents Company's cis-shisool entry is categorized as information-only and does not provide established fragrance or flavor use recommendations for the isolated constituent.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- A directly readable public primary CAS source for the isolated cis-shisool isomer was not verified in this pass, so the CAS field remains null.
- No isolated human, animal, or receptor-level bioactivity study specific to cis-shisool was located in the reviewed public sources.
- Constituent-specific dermal, sensitization, and phototoxicity limits were not located in the reviewed public sources.
- The numeric dermal reference lacks source provenance; a verified flag alone is insufficient.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.