(E)-2-Tridecenal is a long-chain unsaturated aldehyde associated most strongly with coriander leaf and cilantro-like aroma systems rather than with a deep standalone pharmacology literature. Public evidence is strongest for identity, odor character, coriander occurrence, and a modern RIFM fragrance safety assessment that supports its use under reviewed conditions. Direct human-use or wellness evidence is sparse, so this record should stay focused on aroma chemistry, aldehydic reactivity, and safety-review context.
Chemical identity and composition
NIST lists the exact (E)-isomer with formula C13H24O, InChIKey VMUNAKQXJLHODT-VAWYXSNFSA-N, and CAS 7069-41-2. In the AromaForge oil archive it appears in cilantro herb at 3.56%, and recent coriander volatile work also identifies (E)-2-tridecenal among odor-active leaf aldehydes with odor activity values above 1.
Aroma and practical use
- Use the recorded waxy, citrus rind, tangerine, fatty, soapy, cilantro-like descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
rifm safety conclusion
The RIFM full-text assessment states that existing information supports current use of 2-tridecenal in fragrance applications and reports it is not expected to be genotoxic or phototoxic/photoallergenic under the reviewed framework.
Measured: weight-of-evidence safety conclusion
The source assessment applies to its specified exposure and preparation; this entry is not an unrestricted-use clearance.
rifm sensitization threshold
The same RIFM assessment assigned 2-tridecenal a skin-sensitization NESIL of 230 microg/cm2 using analog-based evidence rather than a direct human dataset on isolated 2-tridecenal.
Measured: skin sensitization threshold
The source assessment applies to its specified exposure and preparation; this entry is not an unrestricted-use clearance.
coriander odor activity
A 2023 Food Chemistry snippet reports that coriander samples contained high aldehyde proportions and that (E)-2-tridecenal was among the compounds with odor activity values above 1, indicating a measurable contribution to coriander flavor.
Measured: odor activity value screen
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
RIFM's 2022 safety assessment supports current fragrance use of 2-tridecenal, but key hazard endpoints were informed partly by analog read-across rather than direct constituent-specific human data.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
The public safety context still treats this molecule as an alpha,beta-unsaturated aldehyde with sensitization relevance, so casual 'gentle' or unrestricted topical claims would overstate the evidence.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
aldehydic electrophile behavior
As an alpha,beta-unsaturated aldehyde, (E)-2-tridecenal is handled in safety assessments as a reactive electrophile whose toxicology can be informed by structurally related unsaturated aldehydes and sensitization read-across.
The source assessment applies to its specified exposure and preparation; this entry is not an unrestricted-use clearance.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- No human clinical studies specific to isolated (E)-2-tridecenal were located in the reviewed public sources.
- Direct constituent-specific pharmacology literature was sparse; most non-safety evidence located was odor or occurrence chemistry.
- The archive's existing cilantro oil file currently lists a different CAS number for this constituent than the NIST exact (E)-isomer record, so future normalization may be worth a separate batch.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.