(E)-Nuciferol is a sandalwood-associated sesquiterpene alcohol that appears in Santalum album and related aroma materials, including the Kupang-context sandalwood record already present in the AromaForge archive. The strongest live evidence in this pass is identity and occurrence data, plus whole-oil research showing it can be a meaningful sandalwood component. Direct constituent-level pharmacology for isolated (E)-nuciferol remains sparse in accessible literature, so this record should stay chemistry-first and clearly mark the evidence gap.
Chemical identity and composition
PubChem resolves (E)-Nuciferol to CID 6429177 with formula C15H22O and IUPAC name (E)-2-methyl-7-(4-methylphenyl)hept-2-en-1-ol. Published essential-oil papers place nuciferol isomers in sandalwood, mountain-tea, and Artemisia-related volatile profiles, indicating it is a recurring natural sesquiterpene alcohol rather than a one-off naming artifact.
Aroma and practical use
- Use the recorded woody, soft balsamic, sandalwood-like descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2016 sandalwood-oil study reported that a GC/MS-characterized oil used in breast-cell experiments contained (E)-nuciferol at 10.46% among its main constituents.
This is useful occurrence context because it shows (E)-nuciferol can be a substantial component of tested sandalwood oil, but the biological findings in that paper apply to the whole oil rather than to isolated nuciferol.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2010 GC/GC-MS paper on Sideritis italica reported (Z)-nuciferol at 6.5% in flower oil, supporting the broader natural-occurrence pattern for nuciferol isomers beyond sandalwood.
This helps establish that nuciferol isomers recur in essential-oil literature and are not unique to a single sandalwood dataset.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2004 comprehensive two-dimensional GC study identified Z-nuciferol as one of eight representative components selected for qualitative and quantitative analysis of West Australian sandalwood oil.
This supports nuciferol's relevance as an analytical sandalwood component, even though the paper focused on measurement rather than isolated bioactivity.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
This pass did not verify a constituent-specific IFRA limit, dermal maximum, or human tolerability study for isolated (E)-nuciferol.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Whole-oil studies should not be treated as isolated-(E)-nuciferol safety evidence because sandalwood oil contains multiple major sesquiterpenols.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (6)
- No strong isolated-(E)-nuciferol pharmacology literature was verified in this pass.
- Public constituent-specific safety data are sparse compared with composition-only references.
- Much of the accessible literature discusses nuciferol isomers together or within whole oils rather than separating isolated (E)-nuciferol effects.
- dermal_limit_pct corrected from an unsourced 20 to null, and sensitizing corrected from an unsourced true to null (2026-07-13): no IFRA Standard, RIFM assessment, or CIR opinion specific to (E)-nuciferol (CAS 39599-18-3) was located in two search passes; only identity records (PubChem, Good Scents) were confirmed.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.