epi-beta-Santalol is a minor-to-moderate sandalwood sesquiterpene alcohol that helps define the more detailed chemistry of true sandalwood oils. The evidence located in this pass is strongest for identity, occurrence, and analytical characterization, with only limited mixture-level biological context. That means epi-beta-santalol is best profiled as a sandalwood marker constituent with clear compositional relevance and explicitly modest standalone bioactivity evidence.
Chemical identity and composition
PubChem resolves the stereochemical record to the (Z)-beta-Santalol entry with formula C15H24O, InChIKey OJYKYCDSGQGTRJ-UGJHJVKRSA-N, and registry number 42495-69-2; synonym data include Epi-I(2)-santalol. In accessible literature this constituent is often discussed as epi-beta-santalol or cis-epi-beta-santalol inside sandalwood analytical papers rather than as an isolated pharmacology target. Within the AromaForge archive it appears around 3% to 4% in multiple sandalwood records, including Royal Hawaiian and New Caledonian profiles.
Aroma and practical use
- Use the recorded woody, soft, creamy, sandalwood descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2004 comprehensive two-dimensional GC paper treated epi-beta-santalol as one of eight representative components needed for higher-resolution characterization of West Australian sandalwood oil, supporting its importance as an analytical identity marker.
A 2004 comprehensive two-dimensional GC paper treated epi-beta-santalol as one of eight representative components needed for higher-resolution characterization of West Australian sandalwood oil, supporting its importance as an analytical identity marker.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2012 Journal of Economic Entomology paper reported that sandalwood oil contained epi-beta-santalol at 3.3% and that the oil showed repellency against Tetranychus urticae, but the authors linked the effect to santanol as a mixture of the two main santalols rather than to epi-beta-santalol alone.
A 2012 Journal of Economic Entomology paper reported that sandalwood oil contained epi-beta-santalol at 3.3% and that the oil showed repellency against Tetranychus urticae, but the authors linked the effect to santanol as a mixture of the two main santalols rather than to epi-beta-santalol alone.
This experimental finding does not establish benefit, dose or safety in people using this blend.
Use concerns and concentration limits
Sensitization concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
No constituent-specific RIFM safety assessment, IFRA limit, or human tolerability study was verified for isolated epi-beta-santalol in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Because the accessible bioactivity context is mixture-level and not based on purified epi-beta-santalol dose-response studies, consumer-facing copy should avoid insect-repellent, anti-inflammatory, or other functional claims for the isolated constituent.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
no isolated constituent mechanism verified
No constituent-specific human or robust isolated-compound mechanism was verified for epi-beta-santalol in this pass; the accessible literature is primarily analytical or mixture-level.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (6)
- No isolated-compound human clinical evidence was verified for epi-beta-santalol in this pass.
- Accessible literature is dominated by analytical-occurrence papers rather than dedicated pharmacology or toxicology studies.
- No public constituent-specific dermal limit or phototoxicity threshold was confirmed for this exact stereoisomer.
- dermal_limit_pct corrected from an unsourced 20 to null (2026-07-13); sensitizing:true corroborated by analogy: EU SCCS classifies Australian sandalwood oil as an established contact allergen due to its santalol (alpha+beta isomer family) content, with patch-test positivity of 0.0071-1.53% at 10% concentration, though a 20% HRIPT showed no sensitization in 25 volunteers, so the classification is real but concentration-dependent and not isomer-specific.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.