Ethyl cinnamate is a cinnamic-acid ester that matters in the AromaForge archive because it is a major marker in Kaempferia galanga and a secondary marker in some davana material. Compared with many archive esters, it has a stronger preclinical literature trail, but that evidence is still mostly non-human and should be framed cautiously. The best-supported take is that ethyl cinnamate is both an identity-relevant aroma constituent and an experimentally active phenylpropanoid ester with early anti-angiogenic and anti-inflammatory discussion, not a clinically established therapeutic agent.
Aroma and practical use
- Use the recorded sweet, balsamic, spicy, cinnamon-like, floral descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2024 Journal of Ethnopharmacology report stated that ethyl cinnamate suppressed tumor growth through anti-angiogenesis by attenuating the VEGFR2 signaling pathway in colorectal cancer.
A 2024 Journal of Ethnopharmacology report stated that ethyl cinnamate suppressed tumor growth through anti-angiogenesis by attenuating the VEGFR2 signaling pathway in colorectal cancer.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 2015 open-access algal toxicology study concluded that 1 mg/L ethyl cinnamate effectively inhibited Chlorella vulgaris growth, with 48-hour and 72-hour EC50 values of 2.07 and 1.89 mg/L, and linked the effect mainly to inhibition of the photosynthetic electron transfer chain.
A 2015 open-access algal toxicology study concluded that 1 mg/L ethyl cinnamate effectively inhibited Chlorella vulgaris growth, with 48-hour and 72-hour EC50 values of 2.07 and 1.89 mg/L, and linked the effect mainly to inhibition of the photosynthetic electron transfer chain.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2023 Kaempferia galanga composition study reported trans ethyl cinnamate at 19.50% of the essential oil, confirming its role as a major constituent in a cinnamate-ester chemotype.
A 2023 Kaempferia galanga composition study reported trans ethyl cinnamate at 19.50% of the essential oil, confirming its role as a major constituent in a cinnamate-ester chemotype.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
unverified reference · No source provenance attachedJECFA concluded there is no safety concern at current levels of intake when ethyl cinnamate is used as a flavouring agent.
The source assessment applies to its specified exposure and preparation; this entry is not an unrestricted-use clearance.
A 2024 RIFM fragrance ingredient safety assessment exists for ethyl cinnamate, which supports a modern fragrance-safety review trail even though detailed risk conclusions were not directly readable from the available PubMed page in this pass.
The source assessment applies to its specified exposure and preparation; this entry is not an unrestricted-use clearance.
The clearest directly readable hazard-style finding in this pass comes from environmental toxicology rather than topical human use, so broad safety extrapolation should stay conservative.
The source assessment applies to its specified exposure and preparation; this entry is not an unrestricted-use clearance.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
vegfr2_pathway_attenuation
A recent preclinical colorectal-cancer paper reported that ethyl cinnamate suppressed tumor growth through anti-angiogenesis by attenuating the VEGFR2 signaling pathway.
This experimental finding does not establish benefit, dose or safety in people using this blend.
photosynthetic_electron_transfer_inhibition_in_algae
An open toxicology paper on Chlorella vulgaris concluded that ethyl cinnamate inhibited photosynthesis mainly by affecting the electron transfer chain rather than chloroplast structure.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- No human clinical trial centered on isolated ethyl cinnamate was verified in this pass.
- Some modern activity claims are available only as search-result snippets or secondary discussion, so they should not be treated as strong translational evidence.
- A constituent-specific dermal restriction or inhalation limit for isolated ethyl cinnamate was not verified here.
- The numeric dermal reference lacks source provenance; a verified flag alone is insufficient.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.