Isoamyl tiglate is an unsaturated tiglate ester that helps define the angelate-and-tiglate-rich profile of Roman chamomile oil. Compared with many trace archive constituents, it has a relatively solid public safety paper from RIFM, but its broader bioactivity literature is still sparse. The best-supported profile for AromaForge is therefore identity, Roman chamomile occurrence, odor character, and fragrance-safety framing, with any mechanism language kept conservative and tied to read-across or structural inference rather than wellness claims.
Chemical identity and composition
PubChem resolves the compound to C10H18O2 with IUPAC name 3-methylbutyl (E)-2-methylbut-2-enoate and InChIKey ZARFDQHJMNVNLE-WEVVVXLNSA-N. GSRS and PubChem synonym layers align this record with isoamyl tiglate and isopentyl 2-methylcrotonate. In Roman chamomile, EMA lists it among the dominant volatile esters at 11.7-19.9%.
Aroma and practical use
- Use the recorded herbal, fruity, green, chamomile-like, herbaceous descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
EMA lists isoamyl tiglate among the main Roman chamomile oil constituents at 11.7-19.9%.
This places the molecule among the characteristic esters of Roman chamomile rather than at trace abundance.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
RIFM concluded that isopentyl 2-methylcrotonate (E) was not genotoxic, had exposure below the TTC for repeated-dose, reproductive, and respiratory endpoints, and did not present a skin-sensitization concern under current declared levels of use.
The sensitization conclusion relied partly on read-across to hexyl tiglate plus in vitro and human data on the analog.
The source assessment applies to its specified exposure and preparation; this entry is not an unrestricted-use clearance.
Use concerns and concentration limits
Sensitization concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
unverified reference · No source provenance attachedRIFM reports that isoamyl tiglate is not expected to be genotoxic and that exposure is below TTC thresholds for repeated-dose, reproductive, and local respiratory toxicity endpoints.
The source assessment applies to its specified exposure and preparation; this entry is not an unrestricted-use clearance.
No direct public citation is attached to this entry.
RIFM also concludes that isoamyl tiglate does not present a skin-sensitization concern under current declared fragrance-use levels, based on target-structure analysis and hexyl tiglate read-across data.
The source assessment applies to its specified exposure and preparation; this entry is not an unrestricted-use clearance.
No direct public citation is attached to this entry.
Because the molecule is an alpha,beta-unsaturated ester with structural alerts handled through a safety-assessment framework, consumer-facing copy should stay conservative and avoid implying standalone therapeutic activity.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
expected_ester_hydrolysis
Isoamyl tiglate is expected to undergo esterase-mediated hydrolysis, as reflected in RIFM's metabolism and read-across framework for related aliphatic crotonate esters.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
polarized_alkene_structural_alert_handled_by_data
The RIFM assessment notes polarized-alkene and Michael-addition-style structural alerts for sensitization and genotoxicity screening, but concludes that available target and read-across data supersede those alerts under current fragrance-use conditions.
The source assessment applies to its specified exposure and preparation; this entry is not an unrestricted-use clearance.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- No human clinical efficacy literature was verified for isolated isoamyl tiglate in this pass.
- Most usable evidence is identity, occurrence, and fragrance safety assessment rather than direct pharmacology.
- Mechanistic language beyond ester hydrolysis and structural-alert discussion would overstate the current public evidence base.
- The numeric dermal reference lacks source provenance; a verified flag alone is insufficient.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.