Tetramethoxyallylbenzene is a parsley-seed-associated allylbenzene best supported in the literature as a composition and aroma marker rather than a well-characterized standalone active. Public sources consistently place it among the notable volatile constituents of parsley seed oil, while broader alkenylbenzene reviews flag parsley oils and supplements as an area where exposure assessment matters. The current evidence base is much stronger for identity and occurrence than for isolated human safety or therapeutic data, so AromaForge should frame this constituent conservatively.
Chemical identity and composition
PubChem identifies this constituent as CID 617233 with formula C13H18O4 and IUPAC name 1,2,3,4-tetramethoxy-5-prop-2-enylbenzene. PubChem synonym and CAS records also connect it to the common archive label tetramethoxyallylbenzene and the alternate name 6-methoxyelemicin. Within the archive, parsley seed oil already uses this constituent as a recurring marker, and recent open parsley studies continue to report it as a major GC-MS peak.
Aroma and practical use
- Use the recorded parsley-like, spicy, warm aromatic, herb seed descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2024 Heliyon parsley seed essential oil paper reported 1-allyl-2,3,4,5-tetramethoxybenzene at 13.14% by GC-MS, behind apiol and myristicin, in a Moroccan seed-oil sample that also showed in vitro antioxidant and antimicrobial activity at the whole-oil level.
A 2024 Heliyon parsley seed essential oil paper reported 1-allyl-2,3,4,5-tetramethoxybenzene at 13.14% by GC-MS, behind apiol and myristicin, in a Moroccan seed-oil sample that also showed in vitro antioxidant and antimicrobial activity at the whole-oil level.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 2023 Plants review on alkenylbenzenes reported that parsley seed oils may contain tetramethoxyallylbenzene at 0.1% to 22%, while parsley leaf and root oils may contain none, supporting its use as a seed-oil marker.
A 2023 Plants review on alkenylbenzenes reported that parsley seed oils may contain tetramethoxyallylbenzene at 0.1% to 22%, while parsley leaf and root oils may contain none, supporting its use as a seed-oil marker.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2020 Molecules supercritical fluid extraction paper described parsley seed essential oil as being composed mainly of allylpolyalkoxybenzenes including myristicin, apiole, and 2,3,4,5-tetramethoxyallylbenzene, which the authors linked to parsley's distinct odor and flavor.
A 2020 Molecules supercritical fluid extraction paper described parsley seed essential oil as being composed mainly of allylpolyalkoxybenzenes including myristicin, apiole, and 2,3,4,5-tetramethoxyallylbenzene, which the authors linked to parsley's distinct odor and flavor.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
unverified reference · No source provenance attachedNo constituent-specific human clinical safety study, IFRA restriction, or dedicated toxicology monograph was verified for isolated tetramethoxyallylbenzene in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Because tetramethoxyallylbenzene belongs to the broader allylbenzene/alkenylbenzene exposure context discussed for parsley products, archive copy should avoid implying isolated safety or benefit conclusions that were not directly studied.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
volatile_marker_of_seed_oil_chemotype
The clearest supported role for tetramethoxyallylbenzene in the reviewed literature is analytical and organoleptic, where it helps distinguish parsley seed oil chemotypes and contributes to seed-oil aroma character.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- No isolated human pharmacology or clinical outcome evidence was verified for tetramethoxyallylbenzene.
- No current constituent-specific dermal or inhalation safety threshold was located in public sources reviewed here.
- Most accessible benefit-oriented evidence concerns parsley seed oil mixtures rather than purified tetramethoxyallylbenzene.
- The numeric dermal reference lacks source provenance; a verified flag alone is insufficient.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.