trans-Methyl cinnamate is a sweet balsamic phenylpropanoid ester found in methyl-cinnamate chemotypes of basil and in smaller amounts in balsamic materials such as Peru balsam. The public evidence is strongest for identity, flavor-fragrance use, and preclinical enzyme, antimicrobial, and smooth-muscle studies. Those signals are useful for archive context, but they are not human medical evidence, so AromaForge should position trans-methyl cinnamate as a sensory and chemistry marker with selective preclinical activity data.
Chemical identity and composition
PubChem identifies methyl cinnamate as methyl (E)-3-phenylprop-2-enoate with formula C10H10O2 and InChIKey CCRCUPLGCSFEDV-BQYQJAHWSA-N. The AromaForge archive currently encounters it both as a trace Peru balsam constituent and as a leading component in Sugandha kokila cinnamon berry. Public occurrence literature also links it strongly to methyl-cinnamate basil chemotypes, where it can dominate the volatile profile.
Aroma and practical use
- Use the recorded balsamic, sweet, fruity, strawberry-like descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2009 Journal of Agricultural and Food Chemistry study reported that methyl trans-cinnamate strongly inhibited mushroom tyrosinase and also showed antibacterial activity against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus plus antifungal activity against Candida albicans.
A 2009 Journal of Agricultural and Food Chemistry study reported that methyl trans-cinnamate strongly inhibited mushroom tyrosinase and also showed antibacterial activity against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus plus antifungal activity against Candida albicans.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2014 rat aorta study found that the E-isomer of methyl cinnamate caused concentration-dependent, endothelium-independent vasorelaxation, with the authors favoring inhibition of voltage-dependent calcium influx as the main mechanism.
A 2014 rat aorta study found that the E-isomer of methyl cinnamate caused concentration-dependent, endothelium-independent vasorelaxation, with the authors favoring inhibition of voltage-dependent calcium influx as the main mechanism.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A basil extraction paper identified (E)-methyl cinnamate among the major constituents of methyl-cinnamate basil essential oil, supporting its role as a real chemotype marker rather than a minor incidental volatile.
A basil extraction paper identified (E)-methyl cinnamate among the major constituents of methyl-cinnamate basil essential oil, supporting its role as a real chemotype marker rather than a minor incidental volatile.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
The EMA Peru balsam assessment report lists trans-methyl cinnamate at 0.7% in the essential-oil fraction described there, supporting AromaForge's existing Peru balsam context.
The EMA Peru balsam assessment report lists trans-methyl cinnamate at 0.7% in the essential-oil fraction described there, supporting AromaForge's existing Peru balsam context.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot assessed
Not assessed in the available record.
Penetration enhancementNot assessed
Not assessed in the available record.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
unverified reference · No source provenance attachedThe Good Scents reference presents methyl (E)-cinnamate as a flavor and fragrance material, but this is a trade-use signal rather than a human safety clearance for any exposure route.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
The main public activity studies located were in vitro or animal/ex vivo; consumer-facing copy should not translate tyrosinase, antimicrobial, or vasorelaxation findings into skin, vascular, or infection claims.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
No constituent-specific IFRA-style dermal limit or modern human tolerability trial for isolated trans-methyl cinnamate was verified in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
noncompetitive tyrosinase inhibition
A food-chemistry study found reversible, noncompetitive inhibition of mushroom tyrosinase by methyl trans-cinnamate, supporting a browning-related enzyme mechanism in vitro.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
voltage dependent calcium channel related vasorelaxation
Rat isolated-aorta work reported endothelium-independent relaxation consistent with preferential inhibition of plasmalemmal calcium influx through voltage-dependent calcium channels.
This experimental finding does not establish benefit, dose or safety in people using this blend.
No direct public citation is attached to this entry.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- No human clinical study specific to isolated trans-methyl cinnamate was verified in this pass.
- The strongest mechanistic studies were enzyme and vascular models rather than topical or inhalation human data.
- A public constituent-specific dermal limit was not verified.
- The numeric dermal reference lacks source provenance; a verified flag alone is insufficient.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.