trans-Shisool is a perilla-associated oxygenated monoterpene alcohol that appears in the literature mainly as a composition marker within Perilla frutescens essential oils and as a bioconversion product in perillaldehyde-related aroma chemistry. Public evidence is much stronger for identity, occurrence, and biosynthetic or biotransformation context than for isolated pharmacology or toxicology. For AromaForge, the most defensible framing is that trans-shisool is a shiso-character constituent with meaningful aroma-chemistry relevance and explicit gaps around direct human-use safety or efficacy evidence.
Chemical identity and composition
NIST lists trans-Shisool as C10H18O with CAS 22451-48-5 and a stereospecific trans InChIKey. PubChem exposes a broader shisool skeleton entry whose synonym list includes both cis and trans naming variants as well as multiple registry numbers, so stereochemical registry ambiguity remains part of the public database trail. In the archive, the constituent is relevant to green perilla profiles and broader perilla essential-oil literature that repeatedly includes trans-shisool among characteristic volatiles.
Aroma and practical use
- Use the recorded green, mint-like, fresh, herbal, herbaceous descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2019 Food Chemistry study of ten Perilla frutescens accessions identified trans-shisool among the predominant volatile compounds in the leaf essential oils.
This is the clearest directly readable primary study in this pass linking trans-shisool to real perilla chemoprofiles.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2025 open-access review on Perilla frutescens states that comprehensive phytochemical analyses identified trans-shisool among key perilla essential-oil constituents.
The review is useful for chemistry context and archive positioning, but it is not isolated-molecule efficacy evidence.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2020 Journal of Natural Medicines paper on perilla brewing bioconversion lists trans-shisool as part of the perilla essential-oil component context and supports the broader idea that perilla volatiles undergo yeast-mediated conversion during processing.
The abstract does not quantify isolated trans-shisool activity, so it supports pathway context more than direct molecule-level claims.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
unverified reference · No source provenance attachedNo directly readable isolated toxicology, IFRA standard, dermal maximum, or constituent-specific clinical safety paper for trans-Shisool was verified in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
The Good Scents Company page reviewed in this pass classifies trans-shisool as a natural substance and extractive and reports no fragrance or flavor use recommendation.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Because public registries collapse some cis and trans shisool information into broader records, constituent-specific safety extrapolation should be conservative.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
perillaldehyde-related bioconversion product
Accessible perilla bioconversion literature places trans-shisool in the transformation network around perillaldehyde and perillyl alcohol during yeast-mediated aroma conversion.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- Direct isolated pharmacology papers specific to trans-Shisool were not located in the reviewed public sources.
- Public database records for shisool partially collapse cis and trans information, so some synonym and registry data remain stereochemically messy.
- No constituent-specific modern dermal, inhalation, or oral toxicology package for isolated trans-Shisool was verified in this pass.
- The numeric dermal reference lacks source provenance; a verified flag alone is insufficient.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.