(3Z,6E)-alpha-Farnesene is the cis,trans alpha-farnesene isomer, a plant and insect-associated sesquiterpene hydrocarbon that shows up in floral volatile work and niche aroma records more often than in human-use studies. The strongest live evidence for this exact isomer is ecological and analytical rather than therapeutic: registry sources support identity, plant papers track it as a minor but real alpha-farnesene emission isomer, and insect studies show semiochemical activity in ant-aphid systems. For AromaForge, this constituent is best presented as an identity-and-signaling molecule with clear safety and human-data gaps.
Chemical identity and composition
PubChem lists this record as CID 5362889 with formula C15H24, InChIKey CXENHBSYCFFKJS-OXYODPPFSA-N, and the stereochemical name (3Z,6E)-3,7,11-trimethyldodeca-1,3,6,10-tetraene. Public naming is inconsistent across databases because the same isomer is often written as (Z,E)-alpha-farnesene or cis,trans-alpha-farnesene. NIST search results also index the same stereochemical pattern under an E,Z naming order convention.
Aroma and practical use
- Use the recorded green, fresh, floral, fruity descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2021 Current Biology study reported that Z,E-alpha-farnesene and E,E-alpha-farnesene both suppressed walking dispersal of apterous aphids, while only the major trail-pheromone component Z,E-alpha-farnesene also increased aphid reproduction rate.
A 2021 Current Biology study reported that Z,E-alpha-farnesene and E,E-alpha-farnesene both suppressed walking dispersal of apterous aphids, while only the major trail-pheromone component Z,E-alpha-farnesene also increased aphid reproduction rate.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A kiwifruit flower study reported that (Z,E)-alpha-farnesene represented about 1% to 4% of total alpha-farnesene emissions, supporting it as a measurable minor floral isomer.
A kiwifruit flower study reported that (Z,E)-alpha-farnesene represented about 1% to 4% of total alpha-farnesene emissions, supporting it as a measurable minor floral isomer.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
No isomer-specific IFRA restriction, dermal limit, or human clinical safety study for isolated (3Z,6E)-alpha-farnesene was verified in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
As a highly unsaturated sesquiterpene hydrocarbon, this constituent is plausibly oxidation-prone during storage, but that handling inference is broader than the direct isomer-specific safety literature.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
olfactory behavioral cue
In the accessible insect literature, this isomer functions as a volatile cue that changes aphid dispersal and reproduction-related behavior within an ant-mediated mutualism system.
This experimental finding does not establish benefit, dose or safety in people using this blend.
No direct public citation is attached to this entry.
terpene synthase derived emission
Flower volatile work supports biosynthetic formation of this isomer alongside the dominant trans,trans alpha-farnesene isomer in terpene-synthase-driven emissions.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- Human clinical, dermal, and inhalation safety evidence specific to isolated (3Z,6E)-alpha-farnesene was not located in the reviewed public sources.
- The strongest isomer-specific evidence is ecological rather than fragrance-use or wellness evidence.
- Public naming and CAS mapping for alpha-farnesene isomers remain inconsistent across databases.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.