(Z)-Nuciferol is a sandalwood-linked sesquiterpene alcohol that appears repeatedly across the AromaForge archive in Australian, Mysore, and Hawaiian sandalwood records. The strongest live evidence in this pass is identity and occurrence rather than isolated pharmacology: accessible papers and local COA-backed oil data show that cis-nuciferol can be a recurrent and sometimes substantial sandalwood component, especially in some Australian and Pacific sandalwood contexts. Direct constituent-specific benefit or safety literature remains sparse, so this profile is best kept as a chemistry-and-occurrence record with explicit evidence gaps.
Chemical identity and composition
PubChem resolves cis-Nuciferol through CID 6430906 with formula C15H22O, IUPAC name (Z)-2-methyl-6-(4-methylphenyl)hept-2-en-1-ol, synonym links to cis-Nuciferol, and CAS 122442-36-8. The same record has inconsistent display titling, so the isomer assignment is best anchored to the IUPAC field and synonym list rather than to the default PubChem title string alone. In the archive, (Z)-nuciferol recurs across several sandalwood profiles, including Australian sandalwood around 8.7%, Hawaiian sandalwood around 3.3-6.7%, and Mysore sandalwood at lower supporting levels.
Aroma and practical use
- Use the recorded woody, soft balsamic, sandalwood-like, dry descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2010 Chem Biodiversity paper on Santalum austrocaledonicum in Vanuatu reported that cis-nuciferol was one of the four major heartwood-oil constituents and highlighted an Erromango population in which monocyclic sesquiterpenes, specifically (Z)-beta-curcumen-12-ol and cis-nuciferol, exceeded the santalols.
This is useful because it shows cis-nuciferol as a meaningful chemotype variable rather than a one-off trace constituent.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2010 volatile-oil paper on Sideritis italica identified (Z)-nuciferol at 6.5% in flower oil, supporting a broader natural-occurrence pattern for the cis isomer beyond sandalwood alone.
This supports identity and occurrence breadth, but it does not provide isolated constituent pharmacology.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A PubMed-indexed analytical study of West Australian sandalwood selected Z-nuciferol as one of the representative components for qualitative and quantitative GC analysis of the oil.
That finding reinforces the compound's analytical relevance in sandalwood even though the paper's emphasis was measurement rather than biological activity.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
This pass did not verify a constituent-specific IFRA limit, dermal ceiling, or human tolerability study for isolated (Z)-nuciferol.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Whole-oil sandalwood literature should not be treated as isolated-(Z)-nuciferol safety evidence because the oils contain multiple major sesquiterpenols.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (6)
- No strong isolated-(Z)-nuciferol pharmacology literature was verified in this pass.
- Public constituent-specific safety data are sparse compared with composition-only sandalwood references.
- Some public database naming for this isomer is internally inconsistent, so identity should be read from the IUPAC and synonym fields together rather than from the display title alone.
- No IFRA standard, RIFM monograph, or Tisserand & Young dermal limit specific to (Z)-nuciferol was located; the previous dermal_limit_pct (20%) and sensitizing/phototoxic flags had no supporting citation and have been cleared pending verified data.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.