Allyl methyl trisulfide is a prominent garlic-oil organosulfur constituent and one of the better documented minor garlic sulfur molecules in this batch. Live sources support its identity, recurrent occurrence in garlic oil, flavor-use safety review through JECFA, and several animal or cell studies describing oxidative-stress and inflammatory-pathway effects. Those findings are still preclinical, so the record should avoid turning them into medical claims.
Aroma and practical use
- Use the recorded garlic-like, sulfury, sharp, pungent, sulfurous descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2019 mouse study reported that AMTS attenuated acetaminophen-induced hepatotoxicity, lowered mortality and serum aminotransferases, improved histology, and was associated with suppressed CYP2E1 and activated Nrf2-linked antioxidant defenses.
A 2019 mouse study reported that AMTS attenuated acetaminophen-induced hepatotoxicity, lowered mortality and serum aminotransferases, improved histology, and was associated with suppressed CYP2E1 and activated Nrf2-linked antioxidant defenses.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 2022 open-access study reported that AMTS reduced edema, protein leakage, inflammatory mediators, and macrophage M1 polarization in LPS-induced acute lung injury models while suppressing NF-kB and MAPK signaling markers.
A 2022 open-access study reported that AMTS reduced edema, protein leakage, inflammatory mediators, and macrophage M1 polarization in LPS-induced acute lung injury models while suppressing NF-kB and MAPK signaling markers.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 1986 mouse study reported increased glutathione S-transferase activity in forestomach, small bowel mucosa, liver, and lung after AMT exposure and found more than 70% reduction in benzo[a]pyrene-induced forestomach tumors in that model.
A 1986 mouse study reported increased glutathione S-transferase activity in forestomach, small bowel mucosa, liver, and lung after AMT exposure and found more than 70% reduction in benzo[a]pyrene-induced forestomach tumors in that model.
This experimental finding does not establish benefit, dose or safety in people using this blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
WHO/JECFA lists allyl methyl trisulfide as having no safety concern at current levels of intake when used as a flavouring agent.
The source assessment applies to its specified exposure and preparation; this entry is not an unrestricted-use clearance.
No direct public citation is attached to this entry.
That conclusion is for flavoring exposure and should not be overextended into therapeutic or concentrated-use safety claims.
The source assessment applies to its specified exposure and preparation; this entry is not an unrestricted-use clearance.
No direct public citation is attached to this entry.
No standalone dermal-fragrance safety dossier or numeric dermal limit was verified in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
Nrf2-linked antioxidant response with CYP2E1-related modulation
Nrf2-linked antioxidant response with CYP2E1-related modulation
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
NF-kB and MAPK pathway suppression
NF-kB and MAPK pathway suppression
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (4)
- No human clinical trials specific to isolated allyl methyl trisulfide were verified in this pass.
- The preclinical literature is suggestive but still model-specific and not strong enough for consumer-facing efficacy claims.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.