Allyl sulfide, also commonly listed as diallyl sulfide, is a garlic-derived organosulfur constituent documented in the AromaForge archive from steam-distilled garlic oil. The reviewed evidence is stronger for preclinical cell and animal research than for human use: studies describe calcium-signaling effects in renal tubular cells and anti-inflammatory or antioxidant-related findings in mouse models, but no human clinical evidence specific to isolated allyl sulfide was located in the reviewed public sources. Consumer-facing summaries should treat this as constituent research rather than a medical claim.
Chemical identity and composition
PubChem lists allyl sulfide with molecular formula C6H10S and IUPAC name 3-prop-2-enylsulfanylprop-1-ene. In the archive's garlic-china oil record, allyl sulfide was reported at 0.89% under the GC-MS name 1-Propene, 3,3'-thiobis-, consistent with the common synonym diallyl sulfide.
Aroma and practical use
- Use the recorded garlic, pungent, sulfury, sulfurous descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
calcium signaling in kidney cells
A J Nat Prod abstract comparing diallyl sulfide, diallyl disulfide, and diallyl trisulfide reported a sulfur-number-dependent pattern in intracellular calcium elevation and cell death, with allyl sulfide showing the weakest effect among the three garlic sulfides.
Measured: intracellular calcium signaling and cell viability
This experimental finding does not establish benefit, dose or safety in people using this blend.
intestinal inflammation related research
An abstracted mouse study reported that oral diallyl sulfide reduced inflammation and tissue damage in DNBS colitis, while associated cell work found reduced nitric oxide production and STAT-1 expression in IFN-gamma-stimulated intestinal epithelial cells.
Measured: colon damage, histology, nitric oxide, STAT-1
This experimental finding does not establish benefit, dose or safety in people using this blend.
oxidative stress related research
A Phytother Res abstract reported that garlic-derived allyl sulfides, including diallyl sulfide, lowered reactive oxygen species and malondialdehyde and increased glutathione S-transferase activity in mouse liver, although DADS and DATS produced the stronger sulfane-sulfur changes.
Measured: reactive oxygen species, malondialdehyde, glutathione S-transferase, sulfhydryl groups
This experimental finding does not establish benefit, dose or safety in people using this blend.
Use concerns and concentration limits
Sensitization concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
No constituent-specific IFRA leave-on limit or phototoxic restriction was located in the reviewed public sources for isolated allyl sulfide.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
The archive's garlic oil records and reviewed public safety summaries treat garlic sulfide-rich oils as strong irritants, so constituent-level marketing language should stay conservative and avoid implying topical gentleness.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
calcium signaling modulation
In MDCK renal tubular cells, allyl sulfides showed sulfur-number-dependent effects on intracellular calcium signaling and cell viability, with diallyl sulfide producing the weakest response of the three tested sulfides.
This experimental finding does not establish benefit, dose or safety in people using this blend.
stat1 and nitric oxide related signal
In IFN-gamma-stimulated murine intestinal epithelial cells, the murine colitis paper reported that diallyl sulfide inhibited nitric oxide production and STAT-1 expression.
This experimental finding does not establish benefit, dose or safety in people using this blend.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- No human clinical studies specific to isolated allyl sulfide were located in the reviewed public sources.
- No constituent-specific dermal-sensitization, phototoxicity, or numeric leave-on restriction was located in the reviewed public sources.
- Most mechanistic and efficacy-style findings come from preclinical models and should not be translated into direct consumer health claims.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.