Aromadendrene is a woody sesquiterpene hydrocarbon found in several essential oils already present in the AromaForge archive, including tea tree and curry leaf records. The strongest direct constituent evidence is still preclinical: one PubMed-indexed study reported antimicrobial activity for isolated aromadendrene and additive-to-synergistic interaction with 1,8-cineole against susceptible and resistant pathogens. Beyond that, the public literature is weighted toward identity, occurrence, and broader review summaries of the aromadendrane sesquiterpene family rather than human data.
Chemical identity and composition
PubChem resolves aromadendrene to CID 11095734 with formula C15H24 and a tricyclic aromadendrane-style sesquiterpene structure. NIST lists aromandendrene under CAS 489-39-4, while PubChem synonyms also include 72747-25-2, so the archive keeps the CAS already used in local oil files. In AromaForge oils, aromadendrene is already recorded at 4.5% in curry leaf and in tea tree composition ranges traced to ISO-style reference data.
Aroma and practical use
- Use the recorded woody, herbal, resinous, herbaceous, resin descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2010 Eucalyptus globulus fruit-oil study reported that aromadendrene was the main compound in the oil, showed antimicrobial activity against Gram-positive bacteria including MRSA and VRE, and appeared to contribute more to the activity than 1,8-cineole or globulol.
A 2010 Eucalyptus globulus fruit-oil study reported that aromadendrene was the main compound in the oil, showed antimicrobial activity against Gram-positive bacteria including MRSA and VRE, and appeared to contribute more to the activity than 1,8-cineole or globulol.
This experimental finding does not establish benefit, dose or safety in people using this blend.
The same 2010 study reported that combinations of aromadendrene and 1,8-cineole reduced MIC values additively in checkerboard assays, while time-kill testing indicated synergistic effects.
The same 2010 study reported that combinations of aromadendrene and 1,8-cineole reduced MIC values additively in checkerboard assays, while time-kill testing indicated synergistic effects.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 2024 review summarized tricyclic aromadendrene-type sesquiterpenoids as widely distributed natural products with reported anti-inflammatory, analgesic, antioxidant, antibacterial, insecticidal, and cytotoxic properties at the class level.
A 2024 review summarized tricyclic aromadendrene-type sesquiterpenoids as widely distributed natural products with reported anti-inflammatory, analgesic, antioxidant, antibacterial, insecticidal, and cytotoxic properties at the class level.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
unverified reference · No source provenance attachedNo constituent-specific dermal limit, IFRA restriction, or human tolerability study was located for isolated aromadendrene in the reviewed public sources.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Because the direct biological evidence is limited to in vitro antimicrobial work and review-level family summaries, archive copy should avoid therapeutic or anti-infective claims for isolated aromadendrene.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
These are research candidates recorded in the interaction matrix. They do not add a proven-amplification bonus to the score.
1,8-cineoleAmplification candidate
Candidate in the research matrix. A coefficient alone does not establish amplification at the dose, route or goal of your blend; no proven amplification is inferred from this row.
in vitro · effect
No source citation attached.
Read 1,8-cineole report →How the effects were investigated
membrane level antimicrobial signal
The available direct antimicrobial paper did not define a molecular target, but it identified aromadendrene as the most active of the major Eucalyptus globulus fruit-oil terpenoids and found stronger combined activity with 1,8-cineole in time-kill testing.
This experimental finding does not establish benefit, dose or safety in people using this blend.
No direct public citation is attached to this entry.
no human validated mechanism
No constituent-specific human mechanism or clinical pharmacology for isolated aromadendrene was verified in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (7)
- No human clinical studies specific to isolated aromadendrene were located in the reviewed public sources.
- Direct isolated-constituent evidence is narrow and depends heavily on one antimicrobial paper plus broader family-level review context.
- Constituent-specific sensitization, phototoxicity, and topical-use-limit data were not verified in this pass.
- 2026-07-13 re-verification (worker c3): a targeted search for aromadendrene (CAS 489-39-4) IFRA dermal limit and sensitization/phototoxicity data found a supplier note that it is 'not classified as a hazardous substance' but no authoritative constituent-specific numeric limit or hazard monograph; that supplier note is too weak to change sensitizing/phototoxic fields, so dermal_limit_verified remains false.
- The numeric dermal reference lacks source provenance; a verified flag alone is insufficient.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.
- Interaction candidates lack an attached source citation and remain unqualified.