Isopatchoul-4(5)-en-3-one is a lesser-known sesquiterpene ketone closely associated with nagarmotha and other Cyperus materials. The strongest accessible evidence is structural and compositional rather than pharmacological: older chemistry papers established or revised its identity, and later reports continue to detect it as a meaningful oil constituent, including as a major peak in some Cyperus scariosus samples. AromaForge should therefore frame this molecule as a Cyperus marker constituent with historically important structure elucidation and limited modern standalone bioactivity evidence.
Chemical identity and composition
Publicly accessible chemistry sources consistently place isopatchoul-4(5)-en-3-one in the sesquiterpene ketone cluster of Cyperus constituents and describe a naming history in which the structure was revised from earlier labels such as articulone and cyperenone. Review and archive-accessible snippets support formula C15H22O and describe the compound as an alpha,beta-unsaturated ketone identified in Cyperus scariosus and Cyperus articulatus. In the local nagarmotha-cypriol profile, it is the single largest listed constituent at 16.5%, so it is more than a trace curiosity in the retained aroma context.
Aroma and practical use
- Use the recorded woody, earthy, spicy descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 1965 Tetrahedron Letters paper described isopatchoulenone as a new sesquiterpene ketone from the oil of Cyperus scariosus, anchoring the modern identity history of this constituent.
This is one of the core primary references behind the constituent's accepted name and should be treated as identity evidence rather than a bioactivity paper.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 1988 Phytochemistry paper on Cyperus articulatus reported isolation of mustakone and isopatchoul-4(5)-en-3-one alongside mandassidione and stated that the structures were established from spectroscopic and chemical evidence.
This extends the constituent's occurrence beyond C. scariosus and supports its continued recognition in Cyperus sesquiterpene chemistry.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
The local nagarmotha-cypriol oil profile records isopatchoul-4(5)-en-3-one at 16.5%, making it the leading retained marker in that sample summary.
This is the clearest AromaForge-specific relevance signal for the constituent.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
No constituent-specific human safety study, fragrance-safety review, or dermal limit was verified for isolated isopatchoul-4(5)-en-3-one in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
The currently accessible literature is dominated by structure elucidation and composition reports, so any wellness or symptom-style claims would outrun the evidence.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (6)
- A machine-readable primary database record for this exact name was not verified in the accessible sources reviewed here.
- The public evidence base is much stronger for historical identity and occurrence than for isolated constituent pharmacology.
- A confident CAS number was not verified from a primary source in this pass. A 2026-07-13 search surfaced a candidate CAS (3466-15-7, 'cyperotundone'/'isopatchoulenone') but this appears to be a distinct tricyclic Cyperus ketone rather than a confirmed match for isopatchoul-4(5)-en-3-one, so it was not adopted.
- No IFRA Standard, RIFM fragrance safety assessment, or Tisserand & Young dermal-limit entry was located for isopatchoul-4(5)-en-3-one in this pass; the prior unsourced 2% dermal_limit_pct placeholder has been removed.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.