Methyl m-tolyl sulfide

CAS:
4886-77-5
Family:
aryl sulfide
Also:
1-methyl-3-(methylthio)benzene, 3-methylthioanisole, 3-methylthiotoluene, Methyl m-tolyl sulfide

Found heavily in (1 oils total)

Recorded sensory reference values
  • Affect valence: -0.4
  • Affect arousal: 0.55

Reference values depend on measurement conditions and do not describe an effective dose or the perception of a custom blend.

Methyl m-tolyl sulfide is a relatively obscure aryl sulfide with much thinner public literature than the other two constituents in this batch. The accessible evidence base is strongest for identity and for its use as an oxidation substrate in synthetic and catalytic chemistry, not for fragrance safety or wellness relevance. AromaForge should therefore treat it as a low-context sulfur aromatic with clear identity data, a small mechanistic oxidation literature, and substantial evidence gaps around natural occurrence, human exposure, and constituent-specific safety.

Aroma and practical use

sulfurousthioether-likearomaticroasted
  • Use the recorded sulfurous, thioether-like, aromatic, roasted descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
  • Read the route, preparation and experimental context before using a study finding to choose an oil.

Reported benefits and effects

Findings retain their study context. An animal or laboratory result describes that experiment.

A 1999 JACS paper on an antibody-metalloporphyrin catalytic assembly included methyl m-tolyl sulfide among the aromatic sulfides oxidized to sulfoxides in an enantioselective model system.

A 1999 JACS paper on an antibody-metalloporphyrin catalytic assembly included methyl m-tolyl sulfide among the aromatic sulfides oxidized to sulfoxides in an enantioselective model system.

synthetic mechanisticRoute not recorded

This reference does not establish a therapeutic result or a safe use level for a custom oil blend.

Use concerns and concentration limits

Sensitization concernNot flagged

Not flagged in the current model. This is not proof of absence or unrestricted safety.

Phototoxicity concernNot flagged

Not flagged in the current model. This is not proof of absence or unrestricted safety.

Oxidation concernNot flagged

Not flagged in the current model. This is not proof of absence or unrestricted safety.

Penetration enhancementNot flagged

Not flagged in the current model. This is not proof of absence or unrestricted safety.

No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.

No robust constituent-specific toxicology or dermal-fragrance safety dossier was verified in this pass.
gapRoute not recorded

This reference does not establish a therapeutic result or a safe use level for a custom oil blend.

No direct public citation is attached to this entry.

Because the public evidence base is sparse, this constituent should be summarized conservatively and without benefit or exposure claims.
evidence synthesisRoute not recorded

This reference does not establish a therapeutic result or a safe use level for a custom oil blend.

No direct public citation is attached to this entry.

Constituents it may interact with

No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.

How the effects were investigated

sulfur oxidation to the corresponding sulfoxide

sulfur oxidation to the corresponding sulfoxide

mechanisticRoute not recorded

This reference does not establish a therapeutic result or a safe use level for a custom oil blend.

No direct public citation is attached to this entry.

What this report cannot establish

  • A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
  • The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
  • An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
  • A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
  • Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (6)
  • No primary-source evidence was verified in this pass showing methyl m-tolyl sulfide as a recurrent constituent in specific archive oils.
  • No human, animal, or constituent-specific fragrance-safety studies were verified in this pass.
  • The accessible literature is dominated by synthetic chemistry use as a model sulfide substrate.
  • A dermal-limit safety pass (2026-07-13) searched for IFRA/RIFM/Tisserand/ECHA data specific to methyl m-tolyl sulfide (3-methylthiotoluene, CAS 4886-77-5) and found no constituent-specific dermal limit, sensitization, or phototoxicity source; the prior placeholder dermal_limit_pct of 0.1 had no citation and was cleared to null.
  • No constituent-specific numeric dermal reference is available here.
  • Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.
All public references (3)