3-Vinyl-1,2-dithiacyclohex-4-ene is a garlic-derived sulfur heterocycle formed within the broader allicin-breakdown chemistry of processed or disrupted garlic. The live evidence base supports its identity, repeated occurrence in garlic volatile profiles, and role as a garlic aroma marker more clearly than it supports isolated human-use benefits or safety conclusions. For AromaForge, this constituent is best presented as a characteristic garlic dithiin with limited standalone pharmacology and substantial evidence gaps beyond occurrence and flavor chemistry.
Chemical identity and composition
PubChem identifies this constituent as CID 525328 with formula C6H8S2 and IUPAC name 3-ethenyl-3,6-dihydrodithiine. PubChem synonyms include the archive label 3-Vinyl-1,2-dithiacyclohex-4-ene, the alternate name 3-Vinyl-3,6-dihydro-1,2-dithiine, and CAS 62488-52-2. Within the archive, garlic-china oil already reports this compound at 5.65%, and multiple open garlic volatile studies continue to detect it as a recurrent sulfur marker.
Aroma and practical use
- Use the recorded garlic-like, sulfurous, savory, pungent descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2014 open garlic aroma comparison found 3-Vinyl-1,2-dithiacyclohex-4-ene at 14.89% in Chinese garlic and described it as one of the sulfur compounds elevated relative to Kastamonu garlic.
A 2014 open garlic aroma comparison found 3-Vinyl-1,2-dithiacyclohex-4-ene at 14.89% in Chinese garlic and described it as one of the sulfur compounds elevated relative to Kastamonu garlic.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2023 Heliyon garlic-variety profiling study reported that 3-vinyl-1,2-dithiacyclohex-4-ene was present in nearly all tested garlic varieties except Indian and Chinese samples in that specific dataset, supporting recurrent but variable occurrence across cultivars.
A 2023 Heliyon garlic-variety profiling study reported that 3-vinyl-1,2-dithiacyclohex-4-ene was present in nearly all tested garlic varieties except Indian and Chinese samples in that specific dataset, supporting recurrent but variable occurrence across cultivars.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2018 RSC Advances black-garlic processing paper reported that major organosulfur compounds including 3-vinyl-1,2-dithiacyclohex-4-ene showed a gradually decreasing trend from day 3 to day 42 during processing.
A 2018 RSC Advances black-garlic processing paper reported that major organosulfur compounds including 3-vinyl-1,2-dithiacyclohex-4-ene showed a gradually decreasing trend from day 3 to day 42 during processing.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
unverified reference · No source provenance attachedNo isolated human safety study, constituent-specific IFRA limit, or dedicated toxicology monograph was verified for 3-Vinyl-1,2-dithiacyclohex-4-ene.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Because the accessible literature is dominated by garlic flavor chemistry and whole-oil bioactivity, archive copy should avoid assigning standalone antimicrobial, antiviral, or metabolic benefits to this isolated compound.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
allicin_decomposition_product_within_garlic_sulfur_chemistry
The clearest supported mechanistic context is chemical rather than therapeutic: this compound is one of the sulfur heterocycles generated within garlic's post-disruption allicin-derived volatile network.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (6)
- No isolated constituent-level human clinical evidence was verified for this specific dithiin.
- The directly accessible evidence is mainly identity, occurrence, and processing chemistry rather than purified-compound pharmacology.
- Potential confusion with nearby garlic dithiin isomers means copy should stay precise about the exact CAS-linked constituent.
- Second-pass verification (2026-07-13): searched IFRA Standards Library, RIFM database, and ECHA C&L/registration dossiers by CAS 62488-52-2; no compound-specific entry found. dermal_limit_pct, sensitizing, and phototoxic remain unverified; left unchanged.
- The numeric dermal reference lacks source provenance; a verified flag alone is insufficient.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.