trans-Linalool oxide is a linalool-derived oxygenated monoterpene used in flavor-fragrance references and repeatedly observed in floral, tea, and wood volatile systems. For this AromaForge record, the strongest evidence supports identity, occurrence, aroma relevance, and biosynthetic formation from linalool; direct constituent-specific therapeutic literature remains limited. Because public databases often map the shorthand name to the trans furanoid isomer, this archive entry is best treated as a verified aroma constituent with some naming ambiguity rather than as a separately deep pharmacology record.
Chemical identity and composition
PubChem name searches for trans-linalool oxide resolve to the trans furanoid stereoisomer cluster under CID 6432254, and NIST's trans-linalool oxide (furanoid) record carries CAS 34995-77-2. The Good Scents catalog also lists broader E-linalool oxide entries under other registry numbers, so shorthand naming is not perfectly standardized across flavor-fragrance sources. In the archive, this record appears in Tangerine at 5.919% and Linaloe Wood at 3.96%, both using CAS 34995-77-2 and therefore aligning most closely with the trans furanoid identity.
Aroma and practical use
- Use the recorded floral, woody, sweet, earthy, herbaceous descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
white tea floral note
A white tea aroma study reported that the floral note was mainly contributed by 2-hexanone, benzeneacetaldehyde, trans-linalool oxide, and linalool, supporting real sensory relevance for the constituent.
Measured: odor contribution to floral note
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
microbial biotransformation to trans isomers
A 1998 Phytochemistry paper found that biotransformation of (R)-(-)-linalool by Aspergillus niger yielded almost pure trans-furanoid and trans-pyranoid linalool oxides, supporting trans-linalool oxide as a real metabolic product rather than a naming artifact.
Measured: formation of trans furanoid and trans pyranoid linalool oxides
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
unverified reference · No source provenance attachedThis research pass did not verify a trans-linalool-oxide-specific clinical safety paper separate from the broader linalool oxide or furanoid linalool oxide literature.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Because the archive name is broader than some public stereochemical records, safety interpretation should avoid assuming that every source using 'linalool oxide' refers to the exact same registry scope.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
cyp76c1 linked linalool oxidation
Arabidopsis flower work identified CYP76C1 as a major linalool-metabolizing oxygenase contributing to the formation of linalool oxides and related derivatives, supporting a plausible biosynthetic route for trans-linalool oxide in floral systems.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (6)
- The archive shorthand `trans_linalool_oxide` overlaps heavily with the trans furanoid isomer in public databases, so identity scope is narrower in some sources than the file name suggests.
- No strong constituent-specific human clinical or dedicated toxicology literature for this shorthand record was verified in this pass.
- Public flavor-fragrance registries use both stereospecific and broader linalool-oxide records, which can shift CAS handling across sources.
- Sensitizing status here is inferred from the RIFM assessment of the closely overlapping trans furanoid isomer (same CAS 34995-77-2 used by this record), not a separate dedicated study.
- The numeric dermal reference lacks source provenance; a verified flag alone is insufficient.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.