trans-Rose oxide is a high-impact rose-family odorant best known for giving geranium, rose, elderflower, lychee, and related materials a diffusive rosy-green nuance at low concentration. The live evidence base is strongest for identity, aroma relevance, and human metabolic or sensory studies rather than wellness pharmacology. For AromaForge it is best framed as an odor-character marker and fragrance-relevant constituent with honest notes about isomer naming complexity, because public databases and supplier sheets often mix cis/trans, enantiomer, and E/Z labels.
Chemical identity and composition
PubChem resolves trans-Rose oxide into stereoisomer-specific entries; the general trans-Rose oxide query maps to the trans-(-) record with InChIKey CZCBTSFUTPZVKJ-ZJUUUORDSA-N and synonyms including trans-Rose oxide, rose oxide II, and (E)-Rose oxide. The local archive contains trans/e-rose-oxide reporting in geranium bourbon, geranium Chinese, and geranium South Africa records, but supplier CAS usage is inconsistent across public materials, so the identity should be treated as trans-isomer-focused rather than a single universally stable market CAS.
Aroma and practical use
- Use the recorded rosy, green, lychee-like, geranium-like, rose-like descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2015 human-liver-microsome paper reported that CYP2B6 plays an important role in the metabolism of both cis- and trans-rose oxide.
A 2015 human-liver-microsome paper reported that CYP2B6 plays an important role in the metabolism of both cis- and trans-rose oxide.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 2017 human sensory-electrophysiology study found that (+)- and (-)-rose oxide enantiomers were psychophysically indistinguishable, despite significantly different peripheral electro-olfactogram amplitudes and latencies.
A 2017 human sensory-electrophysiology study found that (+)- and (-)-rose oxide enantiomers were psychophysically indistinguishable, despite significantly different peripheral electro-olfactogram amplitudes and latencies.
Apply this finding only to the studied preparation, participants, route and outcome. It does not establish the same result for a custom oil blend.
A 2000 elderflower aroma study identified cis-rose oxide among the compounds contributing to characteristic elderflower odor, reinforcing rose oxide's role as a high-impact odor family rather than a bulk constituent.
A 2000 elderflower aroma study identified cis-rose oxide among the compounds contributing to characteristic elderflower odor, reinforcing rose oxide's role as a high-impact odor family rather than a bulk constituent.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
PubChem hazard summaries for rose oxide list skin and eye irritation classifications, so concentrated handling should assume irritancy.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
No human therapeutic efficacy literature or standalone IFRA-style trans-rose-oxide monograph was verified in the reviewed public sources.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
cyp2b6 linked human microsomal metabolism
A human liver microsome study reported that CYP2B6 played an important role in the metabolism of both cis- and trans-rose oxide enantiomers.
This experimental finding does not establish benefit, dose or safety in people using this blend.
No direct public citation is attached to this entry.
peripheral olfactory enantiomer response difference
Human electrophysiology work found different peripheral electro-olfactogram responses to rose oxide enantiomers even when subjects could not psychophysically tell them apart.
Apply this finding only to the studied preparation, participants, route and outcome. It does not establish the same result for a custom oil blend.
No direct public citation is attached to this entry.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- Public trans-rose-oxide identity data are complicated by inconsistent use of cis/trans, E/Z, and enantiomer-specific CAS numbers across suppliers and databases.
- No human clinical efficacy studies relevant to wellness positioning were located in this pass.
- Most accessible evidence concerns aroma perception and metabolism rather than broader safety toxicology or therapeutic testing.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.