10-epi-gamma-eudesmol is a eudesmane sesquiterpene alcohol found in agarwood, guaiacwood, geranium, and other sesquiterpene-rich aromatic materials. The strongest accessible evidence in this pass supports its chemical identity, repeated occurrence in volatile oils, and one direct constituent-level tick-repellency bioassay. Broader antioxidant, anti-inflammatory, or cytotoxic discussions mostly come from whole-oil studies where 10-epi-gamma-eudesmol is only one component, so AromaForge should frame it as a chemistry and aroma marker with early preclinical interest rather than an established human-use active.
Chemical identity and composition
ChEBI defines 10-epi-gamma-eudesmol as a eudesmane sesquiterpenoid with a hydroxy group at C-11, a C4-C5 double bond, and inversion of configuration at C-10. ChEBI and The Good Scents Company align on formula C15H26O and CAS 15051-81-7. In the AromaForge oil archive it already appears explicitly in agarwood and guaiacwood records, matching the broader literature that places it in wood, grass, and geranium-type volatile oils.
Aroma and practical use
- Use the recorded woody, sweet, floral descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A PubMed-indexed geranium-oil fractionation study isolated (-)-10-epi-gamma-eudesmol and reported 90% repellency against lone star tick nymphs at 0.103 mg/cm2 of filter paper and 73.3% repellency at 0.052 mg/cm2; the abstract states that repellency was similar to DEET at tested concentrations of at least 0.052 mg/cm2.
This is the clearest direct constituent-level activity evidence found, but it is an arthropod bioassay result rather than a human clinical outcome.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A rose-scented geranium distillation study reported 10-epi-gamma-eudesmol at 4.9-5.5% of the primary oil, supporting its role as a recurrent minor-to-moderate geranium constituent rather than a trace artifact.
This supports identity and natural occurrence, not bioactivity.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A guaiacwood GC report listed 10-epi-gamma-eudesmol at 2.23% alongside guaiol, gamma-eudesmol, beta-eudesmol, and bulnesol, reinforcing its placement in woody sesquiterpene-alcohol profiles.
This gives a directly readable occurrence point that aligns with the local guaiacwood record.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A Hedychium species comparison identified 10-epi-gamma-eudesmol as a marker compound for two Hedychium spicatum rhizome-oil collections, showing that the constituent can help distinguish chemotype variation across plant samples.
This is useful chemotaxonomic context rather than standalone pharmacology.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2024 Psychotria asiatica essential-oil abstract reported a profile containing 15.9% 10-epi-gamma-eudesmol and described nitric-oxide inhibition in LPS-stimulated RAW264.7 macrophages plus SK-LU-1 cytotoxicity for the whole oil.
The oil-level result is relevant context, but the accessible source does not isolate 10-epi-gamma-eudesmol as the confirmed driver of those effects.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot assessed
Not assessed in the available record.
Penetration enhancementNot assessed
Not assessed in the available record.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
unverified reference · No source provenance attachedNo human clinical safety study, constituent-specific dermal limit, or robust toxicology monograph for isolated 10-epi-gamma-eudesmol was verified in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
The Good Scents Company page lists hazard classification as none found, but also lists oral, dermal, and inhalation toxicity as not determined, so this should not be treated as a complete safety clearance.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Where practical safety decisions matter, they should default to the safety profile of the finished essential oil or formula rather than assume purified 10-epi-gamma-eudesmol is well characterized.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
arthropod_repellency_signal
The best constituent-specific mechanism-adjacent evidence is behavioral repellency in a filter-paper tick assay, indicating potential vector-repellent activity rather than a validated human therapeutic pathway.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
no_validated_human_mechanism
This research pass did not verify a well-established constituent-specific human mechanism for 10-epi-gamma-eudesmol.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (6)
- No verified human clinical efficacy or safety data specific to isolated 10-epi-gamma-eudesmol were found in this pass.
- Most accessible anti-inflammatory, antioxidant, antimicrobial, and cytotoxic signals come from whole essential oils that contain this molecule rather than purified constituent testing.
- Aroma descriptors are lightly sourced and should be treated as lower confidence than the identity and occurrence data.
- Second-pass verification (2026-07-13): targeted searches for IFRA Standards Library, RIFM fragrancematerialsafetyresource.elsevier.com (by CAS 15051-81-7), and ECHA C&L found no compound-specific dermal limit, sensitization, or phototoxicity monograph. No sibling-oil IFRA certificate references this constituent by name. dermal_limit_pct, sensitizing, and phototoxic remain unverified estimates; left unchanged.
- The numeric dermal reference lacks source provenance; a verified flag alone is insufficient.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.