Dihydrocolumellarin is a relatively uncommon sesquiterpene lactone best documented as a chemotaxonomic and aroma constituent of Australian Callitris woods and related blue-cypress-type materials. The current public evidence base is useful for chemical identity, occurrence, and limited ecological-bioactivity context, especially termite-repellent literature around Callitris heartwood, but it is thin for direct human-use pharmacology or safety monographs on the isolated molecule. This record should therefore stay grounded in identity and occurrence data, with explicit gaps around constituent-specific mechanism and topical-use safety.
Chemical identity and composition
NIST lists dihydrocolumellarin as C15H22O2 with CAS 66873-38-9 and InChIKey LGGWYHIMEGQREQ-UHFFFAOYSA-N. Historical structure papers describe it as one of the sesquiterpene lactones first isolated from Callitris columellaris heartwood, and later compositional reports place it as a notable constituent in blue-cypress-type Callitris oils.
Aroma and practical use
- Use the recorded woody, balsamic, resinous, dry, lactonic, resin descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Review the flagged use concerns across every contributing oil and the selected dilution.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 1978 Tetrahedron Letters report identified dihydrocolumellarin as one of several new sesquiterpene lactones isolated from Callitris columellaris heartwood, providing the foundational identity and structure literature for this constituent.
A 1978 Tetrahedron Letters report identified dihydrocolumellarin as one of several new sesquiterpene lactones isolated from Callitris columellaris heartwood, providing the foundational identity and structure literature for this constituent.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2011 conference abstract on native Australian Callitris oils reported blue cypress Callitris intratropica oils containing about 12-20% dihydrocolumellarin and described Callitris columellaris oil as dominantly dihydrocolumellarin, supporting its value as a strong compositional marker.
A 2011 conference abstract on native Australian Callitris oils reported blue cypress Callitris intratropica oils containing about 12-20% dihydrocolumellarin and described Callitris columellaris oil as dominantly dihydrocolumellarin, supporting its value as a strong compositional marker.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
NIST cites a 2005 Journal of Wood Science paper on termite-repellent sesquiterpenoids from Callitris glaucophylla heartwood in the dihydrocolumellarin record, which supports an ecological repellency context but does not by itself justify isolated constituent efficacy claims in humans.
NIST cites a 2005 Journal of Wood Science paper on termite-repellent sesquiterpenoids from Callitris glaucophylla heartwood in the dihydrocolumellarin record, which supports an ecological repellency context but does not by itself justify isolated constituent efficacy claims in humans.
This experimental finding does not establish benefit, dose or safety in people using this blend.
Use concerns and concentration limits
Sensitization concernFlagged
Flagged in the constituent reference; assess the source, route and finished-product concentration.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
A recorded constituent reference, not a recommended oil dilution. Product category, source applicability and all contributing oils must be checked before use.
unverified reference · No source provenance attachedThe Good Scents record does not list a determined oral, dermal, or inhalation toxicity value for isolated dihydrocolumellarin, so archive safety language should remain conservative.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
A public fragrance-use recommendation located in this pass states 'not for fragrance use' and 'not for flavor use', but the underlying justification was not exposed in enough detail to translate into a formal AromaForge hazard conclusion.
The source assessment applies to its specified exposure and preparation; this entry is not an unrestricted-use clearance.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
termite repellent wood extract context
NIST links the compound record to a 2005 Journal of Wood Science paper on termite-repellent sesquiterpenoids from Callitris glaucophylla heartwood, supporting an ecological defense context for the constituent class without establishing isolated human-use pharmacology.
This experimental finding does not establish benefit, dose or safety in people using this blend.
No direct public citation is attached to this entry.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (5)
- No human clinical literature for isolated dihydrocolumellarin was located in this pass.
- No constituent-specific dermal limit, IFRA restriction, or detailed toxicology monograph was verified from a primary safety source.
- Most retrieved evidence concerns identity, occurrence, and wood-ecology literature rather than direct pharmacology.
- The numeric dermal reference lacks source provenance; a verified flag alone is insufficient.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.