Spathulenol is a widely distributed oxygenated sesquiterpene alcohol found across many essential oils, including cape chamomile and patchouli-related materials in the AromaForge archive. Compared with many obscure sesquiterpenes, it has a useful constituent-specific literature trail: public sources support its identity, broad occurrence, and multiple preclinical studies covering anti-nociceptive, antimicrobial, immunomodulatory, insect-deterrent, and newer anthelmintic models. The evidence still remains mostly in vitro, animal, or pest-control research rather than human clinical use, so AromaForge should position spathulenol as a well-documented aroma constituent with early pharmacology, not as a medical ingredient.
Chemical identity and composition
PubChem lists spathulenol as C15H24O with InChIKey FRMCCTDTYSRUBE-BGPZULBFSA-N. PubChem also tags it as a volatile oil component and plant metabolite, and its compound page snippet notes reported vasodilator and anaesthetic roles. In the local archive, cape chamomile quantifies spathulenol at 1.4%, while patchouli fingerprint work also lists it among recognized volatile markers.
Aroma and practical use
- Use the recorded woody, herbal, soft-spicy, dry, herbaceous descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2022 Nutritional Neuroscience paper reported that local spathulenol administration reduced formalin-induced cold sensitivity, paw edema, and mechanical hyperalgesia, and the authors linked the effect to opioid receptors and TRPA1, TRPM8, and ASIC pathways.
A 2022 Nutritional Neuroscience paper reported that local spathulenol administration reduced formalin-induced cold sensitivity, paw edema, and mechanical hyperalgesia, and the authors linked the effect to opioid receptors and TRPA1, TRPM8, and ASIC pathways.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 2011 Phytotherapy Research study identified spathulenol from Salvia mirzayanii and reported immunomodulatory effects in peripheral blood lymphocyte assays.
A 2011 Phytotherapy Research study identified spathulenol from Salvia mirzayanii and reported immunomodulatory effects in peripheral blood lymphocyte assays.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 2005 Journal of Agricultural and Food Chemistry paper reported significant mosquito bite deterrent activity for isolated spathulenol against Aedes aegypti and Anopheles stephensi.
A 2005 Journal of Agricultural and Food Chemistry paper reported significant mosquito bite deterrent activity for isolated spathulenol against Aedes aegypti and Anopheles stephensi.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 2023 Natural Product Research paper tested spathulenol directly against Xanthomonas citri and reported antibacterial activity with an MIC of 100 micrograms per milliliter.
A 2023 Natural Product Research paper tested spathulenol directly against Xanthomonas citri and reported antibacterial activity with an MIC of 100 micrograms per milliliter.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 2026 ACS Omega paper described spathulenol as a potent and selective in-vitro hit against first-stage larvae of Angiostrongylus cantonensis, extending the constituent-specific literature into anthelmintic screening.
A 2026 ACS Omega paper described spathulenol as a potent and selective in-vitro hit against first-stage larvae of Angiostrongylus cantonensis, extending the constituent-specific literature into anthelmintic screening.
This experimental finding does not establish benefit, dose or safety in people using this blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
No constituent-specific IFRA limit or standalone human safety dossier for isolated spathulenol was verified in the reviewed public sources.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Although spathulenol has more preclinical literature than many niche sesquiterpenes, the evidence is still not a substitute for validated human dosing or therapeutic safety data.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
These are research candidates recorded in the interaction matrix. They do not add a proven-amplification bonus to the score.
BorneolAmplification candidate
Candidate in the research matrix. A coefficient alone does not establish amplification at the dose, route or goal of your blend; no proven amplification is inferred from this row.
in vitro · whole_oil
No source citation attached.
Read Borneol report →How the effects were investigated
opioid and trp channel related antinociception
The Psidium guineense spathulenol study reported anti-nociceptive effects linked to opioid receptors and TRPA1, TRPM8, and ASIC-sensitive pathways in mouse models.
This experimental finding does not establish benefit, dose or safety in people using this blend.
No direct public citation is attached to this entry.
immune cell modulation
A Salvia mirzayanii immunology paper identified spathulenol as the active fraction and reported modulation of lymphocyte proliferation and cytokine patterns in peripheral blood lymphocyte assays.
This experimental finding does not establish benefit, dose or safety in people using this blend.
No direct public citation is attached to this entry.
membrane or contact active antimicrobial repellent context
Bacterial and insect-deterrent studies suggest a direct contact-active role for spathulenol, but the exact molecular target remains less clearly established than its behavioral or growth-inhibition outcomes.
This experimental finding does not establish benefit, dose or safety in people using this blend.
No direct public citation is attached to this entry.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (7)
- No human clinical trials focused on isolated spathulenol were located.
- Mechanistic work is spread across different assay types and has not yet converged on a single validated target profile.
- Constituent-specific topical, inhalation, and long-term safety assessments remain limited in public sources.
- No IFRA, RIFM, Tisserand & Young, or EU Annex III dermal limit or sensitization determination was found for spathulenol as of 2026-07-13 verification pass; the previous dermal_limit_pct value of 20 and sensitizing:true had no locatable citation and were corrected to null/false.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.
- Interaction candidates lack an attached source citation and remain unqualified.