6,9-Guaiadiene is a guaiane-type sesquiterpene hydrocarbon that appears repeatedly in katrafay, spikenard, and some geranium-style oil profiles in the AromaForge archive. The public evidence base reviewed here is much stronger for identity and occurrence than for isolated pharmacology or toxicology. For now it is best treated as a composition marker constituent with limited standalone literature and clearly stated evidence gaps.
Chemical identity and composition
PubChem and NIST both support 6,9-guaiadiene as a C15H24 sesquiterpene hydrocarbon. In the local archive it appears as a substantial marker in katrafay at 10.14% and is also present in spikenard and several geranium records under closely related naming. Public fragrance-reference pages list the synonym set but do not supply a verified open CAS number in the materials reviewed during this pass.
Aroma and practical use
- Use the recorded woody, dry, green, sesquiterpenic, terpenic, resin descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
The local katrafay record cites a directly readable GC-MS report that places 6,9-guaiadiene at 10.14% of Cedrelopsis grevei bark oil, making it one of the oil's principal markers.
This is the clearest archive-linked occurrence anchor for the constituent.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
The Good Scents Company occurrence page lists 6,9-guaiadiene in geranium oils from multiple origins and in other botanical materials, reinforcing that it is a recurring natural-product sesquiterpene rather than a single-oil anomaly.
This source is useful for occurrence patterning but not a substitute for dedicated toxicology or pharmacology data.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
No constituent-specific human safety study, IFRA restriction, or dedicated dermal sensitization dataset for isolated 6,9-guaiadiene was verified in this pass.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
The Good Scents page shows no determined oral, dermal, or inhalation toxicity values on the accessible page and should be treated as a sparse reference rather than a completed safety review.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (8)
- No strong isolated-compound pharmacology or clinical literature for 6,9-guaiadiene was verified in this pass.
- CAS 36577-33-0 was confirmed via PubChem CID 527113 (name match on '6,9-Guaiadiene', formula C15H24); stereochemistry is undefined in this registry entry, consistent with the archive's generic naming.
- Mechanism claims would be speculative at this stage and are intentionally omitted.
- 2026-07-13 verification pass: web search for IFRA/RIFM dermal limit and sensitization data found no authoritative constituent-specific results for 6,9-guaiadiene (same compound family as guaia-6,9-diene); prior dermal_limit_pct (25) and sensitizing (true) were unsourced placeholders and have been corrected to null.
- 2026-07-13 second-pass verification: retried with a direct CAS-number search ('36577-33-0' IFRA OR RIFM OR fragrance ingredient safety assessment') rather than a name-based search; results returned only unrelated RIFM assessments for other CAS numbers and general RIFM-process pages, confirming no published RIFM/IFRA assessment exists for this shared CAS number. dermal_limit_pct, sensitizing, phototoxic, and penetration_enhancer remain unverified.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.
- Some findings lack a directly linked source; treat those entries as unverified research notes.