beta-Selinene is a woody sesquiterpene hydrocarbon found in several essential oils already represented in the AromaForge archive, including helichrysum, nagarmotha, manuka, celery seed, and lovage root. The live evidence base is stronger for identity and occurrence than for isolated pharmacology. Public studies do show beta-selinene-rich oils with antioxidant, anti-inflammatory, analgesic, or antimicrobial activity, but those findings come from whole-oil systems rather than purified beta-selinene dose-response work. For AromaForge, beta-selinene is best framed as a compositional and aroma marker with cautious mixture-level bioactivity context and clear standalone evidence gaps.
Chemical identity and composition
PubChem lists beta-Selinene as C15H24 with InChIKey YOVSPTNQHMDJAG-QLFBSQMISA-N and an octahydronaphthalene sesquiterpene skeleton. In the local archive it appears at notable levels in helichrysum immortelle Balkan Peninsula (12.2%), nagarmotha cypriol (up to 7.1%), manuka (6.53%), lovage root (5.92%), celery seed (2.0-12.5%), carrot seed (2.2%), and ho-sho leaf (0.8%).
Aroma and practical use
- Use the recorded woody, dry, spicy, herbal, herbaceous descriptors to explore a blend's scent character; perceived strength also depends on the other ingredients.
- Read the route, preparation and experimental context before using a study finding to choose an oil.
Reported benefits and effects
Findings retain their study context. An animal or laboratory result describes that experiment.
A 2010 composition study reported beta-Selinene at 15.7% in Litsea linii leaf oil and 11.4% in twig oil, supporting its role as a major natural-occurrence marker.
A 2010 composition study reported beta-Selinene at 15.7% in Litsea linii leaf oil and 11.4% in twig oil, supporting its role as a major natural-occurrence marker.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
A 2017 Medicines paper described Callicarpa macrophylla oils containing 37.51-57.01% beta-Selinene and reported antioxidant, anti-inflammatory, analgesic, and antipyretic activity for the oils in vitro and in mice.
A 2017 Medicines paper described Callicarpa macrophylla oils containing 37.51-57.01% beta-Selinene and reported antioxidant, anti-inflammatory, analgesic, and antipyretic activity for the oils in vitro and in mice.
This experimental finding does not establish benefit, dose or safety in people using this blend.
A 2024 Helichrysum italicum study reported that beta-Selinene was among the minor compounds associated by ANN modeling with the oil's antimicrobial activity after in vitro testing and ATP-ase-oriented docking analysis.
A 2024 Helichrysum italicum study reported that beta-Selinene was among the minor compounds associated by ANN modeling with the oil's antimicrobial activity after in vitro testing and ATP-ase-oriented docking analysis.
This experimental finding does not establish benefit, dose or safety in people using this blend.
Use concerns and concentration limits
Sensitization concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Phototoxicity concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Oxidation concernNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
Penetration enhancementNot flagged
Not flagged in the current model. This is not proof of absence or unrestricted safety.
No numeric constituent-specific use limit is available here. Missing is not an unrestricted-use clearance.
No authoritative standalone toxicology monograph, human exposure study, or constituent-specific IFRA limit for isolated beta-Selinene was verified in the reviewed public sources.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Because the accessible activity literature is mixture-level, copy should avoid implying direct antimicrobial, anti-inflammatory, or analgesic effects for purified beta-Selinene.
This reference does not establish a therapeutic result or a safe use level for a custom oil blend.
No direct public citation is attached to this entry.
Constituents it may interact with
No constituent-pair interaction is recorded for this identity. The report does not assume either amplification or incompatibility.
How the effects were investigated
mixture level atp ase or membrane targeting prediction
The most specific mechanism signal located for beta-Selinene is indirect: in a Helichrysum italicum oil study it was one of several compounds associated with antimicrobial activity using ATP-ase-focused in silico modeling and ANN attribution.
This experimental finding does not establish benefit, dose or safety in people using this blend.
No direct public citation is attached to this entry.
What this report cannot establish
- A reported constituent percentage does not establish an effective human therapeutic dose or the amount absorbed into the body.
- The presence of a constituent does not guarantee a clinical benefit, rash treatment or sleep improvement from a custom blend.
- An unflagged concern or missing use limit does not establish safety for ingestion, inhalation, skin exposure or a particular person.
- A candidate constituent interaction does not establish that two oils amplify one another at the selected proportions.
- Constituent descriptors alone do not establish a precise top, heart or base lifetime in a finished blend.
Known data gaps (6)
- No human clinical studies for isolated beta-Selinene were located in this pass.
- The strongest biological findings concern beta-selinene-rich oils, not purified beta-Selinene tested alone.
- Constituent-specific dermal, inhalation, and long-term safety literature remains sparse in public sources.
- No IFRA Standard, Tisserand monograph, or RIFM safety assessment specific to beta-Selinene (CAS 17066-67-0) was located; accessible sources (Chemsrc, ChemicalBook, Biosynth, TGSC) provide identity/occurrence data only. sensitizing:true has been corrected to null (unsupported guess) pending real citation.
- No constituent-specific numeric dermal reference is available here.
- Some findings do not record an explicit exposure route; consult the linked study before applying them to a use.